Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 3/20 | 0.63 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.63 |
| ▸ | CA1 | P00915 | 1/20 | 0.63 |
| ▸ | CA2 | P00918 | 1/20 | 0.63 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.63 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.63 |
| ▸ | ITGAL | P20701 | 1/20 | 0.63 |
| ▸ | CA4 | P22748 | 1/20 | 0.63 |
| ▸ | CA6 | P23280 | 1/20 | 0.63 |
| ▸ | ADK | P55263 | 1/20 | 0.63 |
| ▸ | F2 | P00734 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.37 |
| ▸ | WNT3A | P56704 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Indole SCHEMBL28665753 | 0.88 | AHR (0.74) | AHRTRPA1CA1CA2ITGB2 | |
| Indole SCHEMBL15641723 | 0.85 | TRPA1 (0.63) | AHRTRPA1CA1CA2ITGB2 | |
| Indole SCHEMBL28216501 | 0.85 | AHR (0.68) | AHRTRPA1CA1CA2ITGB2 | |
| Indole SCHEMBL6791278 | 0.82 | AHR (0.85) | AHRTRPA1CA1CA2ITGB2 | |
| Indole SCHEMBL7561661 | 0.81 | TRPA1 (0.63) | AHRTRPA1CA1CA2ITGB2 | |
| Indole SCHEMBL5205084 | 0.80 | TRPA1 (0.74) | AHRTRPA1CA1CA2ITGB2 | |
| Indole SCHEMBL27631042 | 0.80 | TRPA1 (0.74) | AHRTRPA1CA1CA2ITGB2 | |
| Indole SCHEMBL2884198 | 0.80 | AHR (0.74) | AHRTRPA1CA1CA2ITGB2 | |
| Indole SCHEMBL6386255 | 0.80 | AHR (0.90) | AHRTRPA1CA1CA2ITGB2 | |
| Indole SCHEMBL1160186 | 0.79 | AHR (1.00) | AHRTRPA1CA1CA2ITGB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 98 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11813304-B2 | Compounds and methods for inhibiting phosphate transport | ARDELYX, INC. (US) | 2023-11-14 | — | — | US | disclosed |
| US-20230277523-A1 | METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX, INC. (US) | 2023-09-07 | — | — | US | disclosed |
| EP-3884935-B1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX INC (US) | 2023-06-14 | — | — | EP | disclosed |
| CN-114340631-A | Combination for reducing serum phosphate in a patient | 阿德利克斯股份有限公司 | 2022-04-12 | — | — | CN | disclosed |
| EP-3884935-A1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | Ardelyx, Inc. (US) | 2021-09-29 | — | — | EP | disclosed |
| US-10894031-B2 | Polyphenol-reactive oxygen species compositions and methods | POWERGUT, INC. (US) | 2021-01-19 | — | — | US | disclosed |
| US-20200368223-A1 | METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX, INC. (US) | 2020-11-26 | — | — | US | disclosed |
| WO-2020237096-A1 | COMBINATION FOR LOWERING SERUM PHOSPHATE IN A PATIENT | ARDELYX, INC. (US) | 2020-11-26 | — | — | WO | disclosed |
| WO-2020150256-A1 | INDOLE MOLECULES AND USE THEREOF IN THE INHIBITION OF DNA POLYMERASES | BIOVENTURES, LLC (US) | 2020-07-23 | — | — | WO | disclosed |
| US-20200038475-A1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX, INC. (US) | 2020-02-06 | — | — | US | disclosed |
| WO-2007030697-A2 | MODULATION OF NEUROGENESIS BY HDAC INHIBITION | BRAINCELLS, INC. (US) | 2007-03-15 | — | — | WO | disclosed |
| US-20070049576-A1 | NEUROGENESIS BY MUSCARINIC RECEPTOR MODULATION | BRAINCELLS, INC. (US) | 2007-03-01 | — | — | US | disclosed |
| WO-2007025177-A2 | NEUROGENESIS BY MUSCARINIC RECEPTOR MODULATION | BRAINCELLS, INC. (US) | 2007-03-01 | — | — | WO | disclosed |
| CN-1869021-A | Preparation method of tegaserod | JIANGSU AOSAIKANG PHARMACEUTIC (CN) | 2006-11-29 | — | — | CN | disclosed |
| WO-2006074127-A2 | BIOMARKERS FOR IDENTIFYING EFFICACY OF TEGASEROD IN PATIENTS WITH CHRONIC CONSTIPATION | NOVARTIS AG (CH) | 2006-07-13 | — | — | WO | disclosed |
| WO-2005004865-A1 | USE OF 5-HT4(A)-SEROTONIN RECEPTOR AGONISTS | GEORG-AUGUST-UNIVERSITÄT GÖTTINGEN (DE) | 2005-01-20 | — | — | WO | disclosed |
| CN-1176077-C | Tegaserod maleate-water crystal | 江苏省药物研究所 | 2004-11-17 | — | — | CN | disclosed |
| WO-2004033498-A2 | .PHARMACEUTICAL COMPOSITION COMPRISING HT4D100A RECEPTORS, AND THERAPEUTIC USES THEREOF | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE-CNRS- (FR) | 2004-04-22 | — | — | WO | disclosed |
| CN-1443535-A | Tegasevod maleate oral preparation and its preparation process-for curing intestinal irritability syndrome | NANCHANG HONGYI SCIENCE & TECH (CN) | 2003-09-24 | — | — | CN | disclosed |
| CN-1425651-A | Tegaserod maleate-water crystal | JIANGSU PROV MEDICINE INST (CN) | 2003-06-25 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200368223-A1 | METHODS FOR INHIBITING PHOSPHATE TRANSPORT | SLC34A3, SLC34A2, SLC34A1 | AHR 4843/4885TRPA1 3284/4885CA1 781/4885 |
| US-11813304-B2 | Compounds and methods for inhibiting phosphate transport | SLC34A3, SLC34A2, SLC34A1 | AHR 4212/4885TRPA1 2880/4885CA1 1474/4885 |
| US-20230277523-A1 | METHODS FOR INHIBITING PHOSPHATE TRANSPORT | SLC34A3, SLC34A2, SLC34A1 | AHR 4843/4885TRPA1 3284/4885CA1 781/4885 |
| US-20070049576-A1 | NEUROGENESIS BY MUSCARINIC RECEPTOR MODULATION | CHRNB2, CHAT, CHRNB4 | AHR 2114/4885TRPA1 1796/4885CA1 1012/4885 |
| US-20200038475-A1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | SLC34A3, SLC34A2, SLC34A1 | AHR 4212/4885TRPA1 2880/4885CA1 1474/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.