Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 6/20 | 0.61 |
| ▸ | DRD3 | P35462 | 5/20 | 0.61 |
| ▸ | DRD4 | P21917 | 2/20 | 0.61 |
| ▸ | ADRB1 | P08588 | 4/20 | 0.45 |
| ▸ | HTR1A | P08908 | 3/20 | 0.45 |
| ▸ | HTR2A | P28223 | 3/20 | 0.45 |
| ▸ | HTR6 | P50406 | 3/20 | 0.45 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.45 |
| ▸ | HTR3B | O95264 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | NCF1 | P14598 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | HTR1D | P28221 | 1/20 | 0.45 |
| ▸ | HTR1B | P28222 | 1/20 | 0.45 |
| ▸ | HTR7 | P34969 | 1/20 | 0.45 |
| ▸ | MTOR | P42345 | 1/20 | 0.45 |
| ▸ | HTR3A | P46098 | 1/20 | 0.45 |
| ▸ | HTR5A | P47898 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6775975 | 1.00 | DRD2 (0.61) | DRD2DRD3DRD4ADRB1HTR1A | |
| SCHEMBL11194827 | 0.86 | DRD2 (0.49) | DRD2DRD3DRD4ADRB1HTR1A | |
| Bromide SCHEMBL11196359 | 0.85 | DRD2 (0.48) | DRD2DRD3DRD4ADRB1HTR1A | |
| Hydrochloric Acid SCHEMBL11196563 | 0.84 | DRD2 (0.47) | DRD2DRD3DRD4ADRB1HTR1A | |
| SCHEMBL20129632 | 0.75 | AHR (0.50) | DRD2DRD3DRD4ADRB1HTR1A | |
| SCHEMBL252278 | 0.75 | DRD2 (0.60) | DRD2DRD3DRD4ADRB1HTR1A | |
| SCHEMBL13244108 | 0.74 | CRBN (0.53) | DRD2DRD3DRD4ALDH1A1LMNA | |
| SCHEMBL5363477 | 0.73 | HTR6 (0.49) | DRD2DRD3DRD4ADRB1HTR1A | |
| SCHEMBL6772080 | 0.72 | ADRB1 (0.49) | DRD2DRD3ADRB1HTR1AHTR2A | |
| SCHEMBL6888226 | 0.72 | CES1 (0.47) | DRD2DRD3DRD4ADRB1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6689792-B2 | USEFUL FOR THE TREATMENT OF SCHIZOPHRENIA AND RELATED PSYCHOTIC DISORDERS SUCH AS PARKINSON'S DISEASE AND ALZHEIMER'S DISEASE | WYETH | 2004-02-10 | — | — | US | disclosed |
| US-20020035112-A1 | Antipsychotic indolyl derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 2002-03-21 | — | — | US | disclosed |
| US-6310066-B1 | 1-(4-CHLORO-PHENOXY)-3-(4-(1H-INDOL-4-YL)-PIPERAZIN-1-YL)-PROPAN-2-OL FOR EXAMPLE | AMERICAN HOME PRODUCTS CORP. | 2001-10-30 | — | — | US | disclosed |
| EP-1076647-A2 | ANTIPSYCHOTIC INDOLYL DERIVATIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-02-21 | — | — | EP | disclosed |
| WO-1999055672-A2 | ANTIPSYCHOTIC INDOLYL DERIVATIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-11-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020035112-A1 | Antipsychotic indolyl derivatives | DRD4, HTR4, DBH | DRD2 12/4885DRD3 7/4885DRD4 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.