Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR132 | Q9UNW8 | 18/20 | 0.52 |
| ▸ | CMKLR2 | P46091 | 1/20 | 0.52 |
| ▸ | CMKLR1 | Q99788 | 1/20 | 0.52 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7832742 | 0.91 | GPR132 (0.45) | GPR132CMKLR2CMKLR1FOLH1 | |
| SCHEMBL7835380 | 0.91 | GPR132 (0.42) | GPR132CMKLR2CMKLR1 | |
| SCHEMBL6775970 | 0.90 | GPR132 (0.49) | GPR132CMKLR2CMKLR1 | |
| SCHEMBL7835677 | 0.89 | GPR132 (0.42) | GPR132CMKLR2CMKLR1 | |
| SCHEMBL6779399 | 0.88 | GPR132 (0.47) | GPR132CMKLR2CMKLR1FOLH1 | |
| SCHEMBL7837213 | 0.88 | CTSL (0.41) | GPR132CMKLR2CMKLR1 | |
| SCHEMBL7834945 | 0.86 | GPR132 (0.52) | GPR132CMKLR2CMKLR1FOLH1 | |
| SCHEMBL6772224 | 0.86 | CTSV (0.50) | GPR132 | |
| SCHEMBL7838300 | 0.86 | ITGB3 (0.51) | GPR132 | |
| SCHEMBL7343445 | 0.86 | GPR132 (0.52) | GPR132CMKLR2CMKLR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0850221-B1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | SEARLE & CO (US) | 2001-07-18 | — | — | EP | claimed |
| EP-0850221-A1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1998-07-01 | — | — | EP | claimed |
| WO-1997008145-A1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1997-03-06 | — | — | WO | claimed |
| US-6831199-B1 | In order to avoid bleeding side-effects when treating the conditions associated with integrin alpha v beta 3, it is beneficial to have compounds which are selective antagonists for alpha v beta 3 versus alpha IIb beta 3 | G. D. SEARLE & CO. | 2004-12-14 | — | — | US | disclosed |
| EP-0850221-B1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | SEARLE & CO (US) | 2001-07-18 | — | — | EP | disclosed |
| US-6028223-A | AN INTEGRIN ANTAGONISTS TREATING BONE DISORDER, PERIODONTAL DISEASE, OSTEOPOROSIS, HUMORAL HYPERCALCEMIA OF MALIGNANCY, PAGET'S DISEASE, TUMOR ANGIOGENESIS, DIABETIC RETINOPATHY, ARTHRITIS, SMOOTH MUSCLE CELL MIGRATION AND RESTENOSIS | G. D. SEARLE & CO. (US) | 2000-02-22 | — | — | US | disclosed |