Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 1/20 | 0.53 |
| ▸ | CASP7 | P55210 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | HSD17B1 | P14061 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | GRM5 | P41594 | 1/20 | 0.45 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.44 |
| ▸ | MIF | P14174 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 5/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | PRKCI | P41743 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.40 |
| ▸ | TERT | O14746 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11872289 | 0.89 | MAOB (0.56) | CASP1CASP7HSD17B10HSD17B1ALDH1A1 | |
| SCHEMBL14741324 | 0.89 | MAOB (0.51) | CASP1CASP7HSD17B10HSD17B1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL11463421 | 0.87 | MAOB (0.54) | CASP1CASP7HSD17B10HSD17B1ALDH1A1 | |
| SCHEMBL3994800 | 0.86 | HSD17B1 (0.63) | CASP1CASP7HSD17B10HSD17B1GRM5 | |
| SCHEMBL5444174 | 0.85 | PBRM1 (0.53) | CASP1CASP7HSD17B10ALDH1A1CYP26A1 | |
| SCHEMBL17080971 | 0.81 | TERT (0.42) | CASP1CASP7HSD17B10HSD17B1ALDH1A1 | |
| SCHEMBL4811389 | 0.80 | ALDH1A1 (0.50) | CASP1CASP7HSD17B10HSD17B1ALDH1A1 | |
| SCHEMBL26332447 | 0.76 | BID (0.43) | CASP1CASP7HSD17B10HSD17B1GRM5 | |
| SCHEMBL30357081 | 0.76 | BID (0.43) | CASP1CASP7HSD17B10HSD17B1GRM5 | |
| SCHEMBL3966947 | 0.76 | RXRA (0.47) | CASP1CASP7HSD17B10HSD17B1GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728150-B2 | Bicyclic substituted indole-derivative steroid hormone nuclear receptor modulators | ELI LILLY AND COMPANY (US) | 2010-06-01 | — | — | US | disclosed |
| US-20070185161-A1 | Bicyclic substituted indole-derivative steroid hormone nuclear receptor modulators | ELI LILLY AND COMPANY | 2007-08-09 | — | — | US | disclosed |
| US-6716852-B2 | FOR THERAPY OF ARTERIAL HYPERTENSION AND CARDIOVASCULAR DISEASES | LES LABORATORIES SERVIER (FR) | 2004-04-06 | — | — | US | disclosed |
| US-6642251-B1 | Antitumor, 2-indolinone derivatives | SUGEN, INC. | 2003-11-04 | — | — | US | disclosed |
| US-20030199510-A1 | Geometrically restricted 2-indolinone derivatives as modulators of protein kinase activity | SUGEN, INC. | 2003-10-23 | — | — | US | disclosed |
| EP-1255757-B1 | AMINO ACID DERIVATIVES AND USE THEREOF AS NEP, ACE AND ECE INHIBITORS | INST NAT SANTE RECH MED (FR) | 2003-06-18 | — | — | EP | disclosed |
| US-20030055086-A1 | Amino acid derivatives and use thereof as nep, ace and ece inhibitors | LES LABORATOIRES SERVIER (FR) | 2003-03-20 | — | — | US | disclosed |
| US-6525072-B1 | Prevention and treatment of cellular disorders such as cancer | SUGEN, INC. | 2003-02-25 | — | — | US | disclosed |
| EP-1255757-A1 | AMINO ACID DERIVATIVES AND USE THEREOF AS NEP, ACE AND ECE INHIBITORS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 2002-11-13 | — | — | EP | disclosed |
| WO-2001060822-A1 | AMINO ACID DERIVATIVES AND USE THEREOF AS NEP, ACE AND ECE INHIBITORS | INSTITUT NATIONAL DE LA RECHERCHE MEDICALE INSERM (FR) | 2001-08-23 | — | — | WO | disclosed |
| EP-1117397-A1 | GEOMETRICALLY RESTRICTED 2-INDOLINONE DERIVATIVES AS MODULATORS OF PROTEIN KINASE ACTIVITY | Sugen, Inc. (US) | 2001-07-25 | — | — | EP | disclosed |
| WO-2000012084-A1 | GEOMETRICALLY RESTRICTED 2-INDOLINONE DERIVATIVES AS MODULATORS OF PROTEIN KINASE ACTIVITY | SUGEN, INC. (US) | 2000-03-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070185161-A1 | Bicyclic substituted indole-derivative steroid hormone nuclear receptor modulators | NR5A1, NR3C2, NR1H2 | CASP1 3877/4885CASP7 4610/4885HSD17B10 115/4885 |
| US-20030055086-A1 | Amino acid derivatives and use thereof as nep, ace and ece inhibitors | MME, ACE, ECE1 | CASP1 2532/4885CASP7 3289/4885HSD17B10 1543/4885 |
| US-20030199510-A1 | Geometrically restricted 2-indolinone derivatives as modulators of protein kinase activity | MAP4K2, CKS2, MAP4K1 | CASP1 3662/4885CASP7 2274/4885HSD17B10 1613/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.