Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
| ▸ | GRIA2 | P42262 | 4/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.30 |
| ▸ | BUB1 | O43683 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7490727 | 0.88 | L3MBTL1 (0.36) | DHODHGRIA2CYP1A2CYP2C9CYP2D6 | |
| SCHEMBL6164978 | 0.88 | DHODH (0.41) | DHODHBUB1 | |
| SCHEMBL6771481 | 0.84 | OPRM1 (0.43) | DHODHBUB1HSP90AB1 | |
| SCHEMBL6771234 | 0.84 | CSNK2A2 (0.35) | BUB1 | |
| SCHEMBL6769804 | 0.83 | PPARA (0.38) | DHODHBUB1 | |
| SCHEMBL6770489 | 0.83 | DHODH (0.35) | DHODHBUB1 | |
| SCHEMBL6776388 | 0.82 | OPRM1 (0.38) | DHODHBUB1 | |
| SCHEMBL6771327 | 0.82 | DHODH (0.32) | DHODH | |
| SCHEMBL6770539 | 0.81 | SRC (0.39) | DHODH | |
| SCHEMBL6767248 | 0.80 | DHODH (0.35) | DHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6716856-B1 | CELL PROLIFERATIVE DISORDERS OR ALZHEIMER'S DISEASE; REDUCED TOXICITY; CDK/CYCLIN KINASE INHIBITORY ACTIVITY | PHARMACIA & TUBJOHN SPA (IT) | 2004-04-06 | — | — | US | disclosed |
| EP-1177185-A1 | 4, 5, 6, 7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA & UPJOHN S.p.A. (IT) | 2002-02-06 | — | — | EP | disclosed |
| WO-2000069846-A1 | 4,5,6,7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA & UPJOHN S.P.A. (IT) | 2000-11-23 | — | — | WO | disclosed |