Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.44 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.44 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6777275 | 0.98 | ALDH1A1 (0.47) | ALDH1A1SLC1A3SLC1A2SLC1A1ALOX5 | |
| SCHEMBL5224032 | 0.86 | ALDH1A1 (0.52) | ALDH1A1SLC1A3SLC1A2SLC1A1ALOX5 | |
| SCHEMBL12864431 | 0.86 | ALDH1A1 (0.52) | ALDH1A1SLC1A3SLC1A2SLC1A1ALOX5 | |
| Hydrochloric Acid SCHEMBL4249637 | 0.84 | ALDH1A1 (0.51) | ALDH1A1SLC1A3SLC1A2SLC1A1ALOX5 | |
| SCHEMBL24591314 | 0.82 | CTSS (0.49) | ALDH1A1SLC1A3SLC1A2SLC1A1ALOX5 | |
| SCHEMBL24591312 | 0.82 | CTSS (0.49) | ALDH1A1SLC1A3SLC1A2SLC1A1ALOX5 | |
| SCHEMBL31290369 | 0.81 | ALDH1A1 (0.50) | ALDH1A1SLC1A3SLC1A2SLC1A1ALOX5 | |
| SCHEMBL10926891 | 0.80 | ALDH1A1 (0.50) | ALDH1A1SLC1A3SLC1A2SLC1A1ALOX5 | |
| SCHEMBL12240912 | 0.80 | ALDH1A1 (0.50) | ALDH1A1SLC1A3SLC1A2SLC1A1ALOX5 | |
| SCHEMBL2668227 | 0.79 | ALDH1A1 (0.46) | ALDH1A1TSHRSMN1; SMN2L3MBTL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12612411-B1 | Imidazopyrazine derivatives, process for preparation thereof, and their uses as luciferins | INSTITUT PASTEUR (FR) | 2026-04-28 | — | — | US | disclosed |
| US-12576164-B2 | Imidazopyrazine derivatives, process for preparation thereof, and their uses as luciferins | INSTITUT PASTEUR (FR) | 2026-03-17 | — | — | US | disclosed |
| EP-3964501-B1 | IMIDAZOPYRAZINE DERIVATIVES, PROCESS FOR PREPARATION THEREOF, AND THEIR USES AS LUCIFERINS | PASTEUR INSTITUT (FR) | 2024-09-04 | — | — | EP | disclosed |
| US-20240197923-A1 | IMIDAZOPYRAZINE DERIVATIVES, PROCESS FOR PREPARATION THEREOF, AND THEIR USES AS LUCIFERINS | INSTITUT PASTEUR (FR) | 2024-06-20 | — | — | US | disclosed |
| US-11938199-B2 | Imidazopyrazine derivatives, process for preparation thereof, and their uses as luciferins | INSTITUT PASTEUR (FR) | 2024-03-26 | — | — | US | disclosed |
| EP-3964501-A1 | IMIDAZOPYRAZINE DERIVATIVES, PROCESS FOR PREPARATION THEREOF, AND THEIR USES AS LUCIFERINS | INSTITUT PASTEUR (FR) | 2022-03-09 | — | — | EP | disclosed |
| EP-3615516-B1 | IMIDAZOPYRAZINE DERIVATIVES, PROCESS FOR PREPARATION THEREOF, AND THEIR USES AS LUCIFERINS | PASTEUR INSTITUT (FR) | 2021-11-17 | — | — | EP | disclosed |
| US-20200129644-A1 | IMIDAZOPYRAZINE DERIVATIVES, PROCESS FOR PREPARATION THEREOF, AND THEIR USES AS LUCIFERINS | INSTITUT PASTEUR (FR) | 2020-04-30 | — | — | US | disclosed |
| EP-3615516-A1 | IMIDAZOPYRAZINE DERIVATIVES, PROCESS FOR PREPARATION THEREOF, AND THEIR USES AS LUCIFERINS | Institut Pasteur (FR) | 2020-03-04 | — | — | EP | disclosed |
| WO-2018197727-A1 | IMIDAZOPYRAZINE DERIVATIVES, PROCESS FOR PREPARATION THEREOF, AND THEIR USES AS LUCIFERINS | INSTITUT PASTEUR (FR) | 2018-11-01 | — | — | WO | disclosed |
| US-9233913-B2 | Amino acid derivatives for the treatment of neuropathic pain | Kong, Xianqi (CA) | 2016-01-12 | — | — | US | disclosed |
| US-9233913-B2 | Amino acid derivatives for the treatment of neuropathic pain | Kong, Xianqi (CA) | 2016-01-12 | — | — | US | disclosed |
| US-20140171507-A1 | AMINO ACID DERIVATIVES FOR THE TREATMENT OF NEUROPATHIC PAIN | Kong, Xianqi (CA) | 2014-06-19 | — | — | US | disclosed |
| US-20140171507-A1 | AMINO ACID DERIVATIVES FOR THE TREATMENT OF NEUROPATHIC PAIN | Kong, Xianqi (CA) | 2014-06-19 | — | — | US | disclosed |
| US-20120208876-A1 | AMINO ACID DERIVATIVES FOR THE TREATMENT OF NEUROPATHIC PAIN | Kong, Xianqi (CA) | 2012-08-16 | — | — | US | disclosed |
| US-20120208876-A1 | AMINO ACID DERIVATIVES FOR THE TREATMENT OF NEUROPATHIC PAIN | Kong, Xianqi (CA) | 2012-08-16 | — | — | US | disclosed |
| WO-2010127439-A1 | AMMO ACID DERIVATIVES FOR THE TREATMENT OF NEUROPATHIC PAIN | BELLUS HEALTH (INTERNATIONAL) LIMITED (CH) | 2010-11-11 | — | — | WO | disclosed |
| US-6831199-B1 | In order to avoid bleeding side-effects when treating the conditions associated with integrin alpha v beta 3, it is beneficial to have compounds which are selective antagonists for alpha v beta 3 versus alpha IIb beta 3 | G. D. SEARLE & CO. | 2004-12-14 | — | — | US | disclosed |
| EP-0850221-B1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | SEARLE & CO (US) | 2001-07-18 | — | — | EP | disclosed |
| US-6028223-A | AN INTEGRIN ANTAGONISTS TREATING BONE DISORDER, PERIODONTAL DISEASE, OSTEOPOROSIS, HUMORAL HYPERCALCEMIA OF MALIGNANCY, PAGET'S DISEASE, TUMOR ANGIOGENESIS, DIABETIC RETINOPATHY, ARTHRITIS, SMOOTH MUSCLE CELL MIGRATION AND RESTENOSIS | G. D. SEARLE & CO. (US) | 2000-02-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11938199-B2 | Imidazopyrazine derivatives, process for preparation thereof, and their uses as luciferins | NISCH, HLCS, CYP3A5 | ALDH1A1 972/4885SLC1A3 4497/4885SLC1A2 4287/4885 |
| US-20200129644-A1 | IMIDAZOPYRAZINE DERIVATIVES, PROCESS FOR PREPARATION THEREOF, AND THEIR USES AS LUCIFERINS | NISCH, HLCS, CYP3A5 | ALDH1A1 972/4885SLC1A3 4497/4885SLC1A2 4287/4885 |
| US-12576164-B2 | Imidazopyrazine derivatives, process for preparation thereof, and their uses as luciferins | LUC7L2, HLCS, LANCL1 | ALDH1A1 659/4885SLC1A3 4509/4885SLC1A2 4521/4885 |
| US-12612411-B1 | Imidazopyrazine derivatives, process for preparation thereof, and their uses as luciferins | LUC7L2, MRPL21, CRY1 | ALDH1A1 1484/4885SLC1A3 3928/4885SLC1A2 4026/4885 |
| US-20140171507-A1 | AMINO ACID DERIVATIVES FOR THE TREATMENT OF NEUROPATHIC PAIN | GAP43, OPRL1, NGF | ALDH1A1 2327/4885SLC1A3 10/4885SLC1A2 5/4885 |
| US-20240197923-A1 | IMIDAZOPYRAZINE DERIVATIVES, PROCESS FOR PREPARATION THEREOF, AND THEIR USES AS LUCIFERINS | NISCH, HLCS, CYP3A5 | ALDH1A1 972/4885SLC1A3 4497/4885SLC1A2 4287/4885 |
| US-20120208876-A1 | AMINO ACID DERIVATIVES FOR THE TREATMENT OF NEUROPATHIC PAIN | GAP43, OPRL1, NGF | ALDH1A1 2327/4885SLC1A3 10/4885SLC1A2 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.