Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 3/20 | 0.41 |
| ▸ | FPR2 | P25090 | 1/20 | 0.41 |
| ▸ | TTR | P02766 | 1/20 | 0.38 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.38 |
| ▸ | GRN | P28799 | 1/20 | 0.37 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.37 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.36 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.36 |
| ▸ | MRE11 | P49959 | 1/20 | 0.35 |
| ▸ | FTO | Q9C0B1 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6779382 | 0.98 | CA2 (0.41) | CA2FPR2TTRFOLH1GRN | |
| SCHEMBL1097052 | 0.86 | CA2 (0.40) | CA2FPR2TTRMRE11FTO | |
| SCHEMBL23045322 | 0.84 | CA2 (0.43) | CA2FPR2TTRFOLH1AKR1C2 | |
| SCHEMBL23045324 | 0.84 | CA2 (0.43) | CA2FPR2TTRFOLH1AKR1C2 | |
| SCHEMBL5144526 | 0.81 | LMNA (0.50) | CA2FPR2FOLH1FTOCA1 | |
| SCHEMBL5144531 | 0.81 | LMNA (0.50) | CA2FPR2FOLH1FTOCA1 | |
| SCHEMBL29855078 | 0.78 | PPARG (0.50) | CA2FOLH1GRNSORT1GAA | |
| SCHEMBL3311174 | 0.77 | ADRB2 (0.43) | AKR1C2 | |
| SCHEMBL11134765 | 0.76 | CTSL (0.50) | FPR2FOLH1 | |
| SCHEMBL4490755 | 0.76 | MRE11 (0.43) | CA2FPR2MRE11HTTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6831199-B1 | In order to avoid bleeding side-effects when treating the conditions associated with integrin alpha v beta 3, it is beneficial to have compounds which are selective antagonists for alpha v beta 3 versus alpha IIb beta 3 | G. D. SEARLE & CO. | 2004-12-14 | — | — | US | disclosed |