Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.57 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.56 |
| ▸ | SMO | Q99835 | 6/20 | 0.55 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6476328 | 0.86 | PKM (0.59) | MAPK14SMN1; SMN2HPGDALDH1A1MEN1 | |
| SCHEMBL28653236 | 0.80 | ABCB1 (0.74) | ABCB1SMN1; SMN2TP53ALDH1A1MEN1 | |
| SCHEMBL6485998 | 0.77 | MAPT (0.77) | SMN1; SMN2NPC1RAB9AHSD17B10HPGD | |
| SCHEMBL10605968 | 0.76 | GAA (0.66) | SMN1; SMN2TP53HTTALDH1A1MEN1 | |
| SCHEMBL29960273 | 0.76 | MAPT (0.57) | MAPK14SMN1; SMN2TP53HTTHPGD | |
| SCHEMBL5789916 | 0.76 | MAPT (0.57) | MAPK14SMN1; SMN2TP53HTTRAB9A | |
| SCHEMBL11574114 | 0.75 | PYGL (0.57) | MAPK14SMN1; SMN2NPC1USP2HTT | |
| SCHEMBL28863360 | 0.75 | ALDH1A1 (0.62) | SMN1; SMN2NPC1TP53HTTRAB9A | |
| SCHEMBL10780310 | 0.75 | HPGD (0.53) | HTTHPGDALDH1A1MEN1KMT2A | |
| SCHEMBL5646672 | 0.74 | MAPT (0.56) | SMN1; SMN2HTTRAB9AHPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6686467-B2 | INHIBITORS OF THE PRODUCTION OF CYTOKINES SUCH AS TUMOUR NECROSIS FACTOR (HEREINAFTER TNF), FOR EXAMPLE TNF ALPHA , AND VARIOUS MEMBERS OF THE INTERLEUKIN (HEREINAFTER IL) FAMILY, FOR EXAMPLE IL-1, IL-6 AND IL-8 | ZENECA LIMITED (GB) | 2004-02-03 | — | — | US | disclosed |
| US-20030166730-A1 | Amide derivatives for the treatment of diseases mediated by cytokines | ZENECA LIMITED | 2003-09-04 | — | — | US | disclosed |
| US-6498274-B1 | Amide derivatives for the treatment of diseases mediated by cytokines | ZENECA LIMITED (GB) | 2002-12-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030166730-A1 | Amide derivatives for the treatment of diseases mediated by cytokines | IL2, IL6, IL6ST | MAPK14 965/4885ABCB1 2272/4885SMO 4065/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.