Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | TDO2 | P48775 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | GRK6 | P43250 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6542516 | 0.80 | TDO2 (0.53) | ALDH1A1KDM4EHPGDHIF1AEPAS1 | |
| SCHEMBL2430190 | 0.79 | NPC1 (0.53) | ALDH1A1KDM4EHPGDIDO1TDO2 | |
| SCHEMBL9264078 | 0.71 | KDM4E (0.41) | ALDH1A1KDM4EHPGDIDO1TDO2 | |
| SCHEMBL6777206 | 0.71 | NPC1 (0.55) | ALDH1A1KDM4EIDO1TDO2MAPT | |
| SCHEMBL4037256 | 0.67 | ALDH1A1 (0.57) | ALDH1A1KDM4EHPGDGAAESR2 | |
| SCHEMBL6777433 | 0.67 | TDO2 (0.48) | ALDH1A1KDM4EHPGDIDO1TDO2 | |
| SCHEMBL5313883 | 0.66 | KDM4E (1.00) | ALDH1A1KDM4EHPGDGAAPOLB | |
| SCHEMBL11219648 | 0.65 | KDM4E (0.64) | ALDH1A1KDM4EHPGDKMT2ACLK4 | |
| SCHEMBL11433999 | 0.65 | LCK (0.56) | ALDH1A1KDM4EHIF1AEPAS1GAA | |
| SCHEMBL30932089 | 0.65 | LCK (0.56) | ALDH1A1KDM4EHIF1AEPAS1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6723736-B2 | FOR THERAPY INFLAMMATION, INFLAMMATORY DISEASES, IMMUNOLOGIC DISEASES AND OTHER DISEASES MEDIATED BY TUMOR NECROSIS FACTOR-ALPHA (TNF-ALPHA) AND/OR INTERLEUKIN 6 OR 10 AND/OR ENZYME CYCLOOXYGENASE-2 (COX-2) | THERACOS, INC. | 2004-04-20 | — | — | US | claimed |
| US-20020077333-A1 | Tricyclic compounds and uses thereof | THERACOS, INC. | 2002-06-20 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020077333-A1 | Tricyclic compounds and uses thereof | IL6, TNF, IL2 | ALDH1A1 1436/4885KDM4E 3276/4885HPGD 74/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.