Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPX4 | P36969 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.48 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.47 |
| ▸ | FAAH | O00519 | 2/20 | 0.47 |
| ▸ | CDK4 | P11802 | 2/20 | 0.45 |
| ▸ | CCND1 | P24385 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6783193 | 0.89 | HDAC6 (0.53) | GPX4HDAC1HDAC6HDAC3HDAC4 | |
| SCHEMBL6787946 | 0.85 | KDR (0.51) | HDAC1HDAC6LMNABAZ2B | |
| Trifluoroacetic Acid SCHEMBL7102782 | 0.80 | KDR (0.46) | HDAC1HDAC6LMNABAZ2B | |
| SCHEMBL4674850 | 0.78 | HDAC3 (0.52) | GPX4HDAC1HDAC6HDAC3HDAC4 | |
| SCHEMBL4674847 | 0.78 | HDAC3 (0.52) | GPX4HDAC1HDAC6HDAC3HDAC4 | |
| SCHEMBL6787801 | 0.78 | DRD2 (0.39) | KDM4EMAPT | |
| Hydrogen Peroxide SCHEMBL7101042 | 0.78 | DRD2 (0.39) | KDM4EMAPT | |
| Hydrogen Peroxide SCHEMBL7101046 | 0.78 | DRD2 (0.39) | KDM4EMAPT | |
| SCHEMBL6788423 | 0.78 | HDAC1 (0.40) | HDAC1HDAC6HDAC3HDAC2 | |
| SCHEMBL6787798 | 0.78 | DRD2 (0.39) | KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040176362-A1 | Hydroxamic and carboxylic acid derivatives | BATTY DUNCAN (GB) | 2004-09-09 | — | — | US | claimed |
| EP-1286994-A1 | HYDROXAMIC AND CARBOXYLIC ACID DERIVATIVES HAVING MMP AND TNF INHIBITORY ACTIVITY | Darwin Discovery Limited (GB) | 2003-03-05 | — | — | EP | claimed |
| US-20030032652-A1 | Hydroxamic and carboxylic acid derivatives | BATTY DUNCAN (GB) | 2003-02-13 | — | — | US | claimed |
| US-6469020-B2 | AS INHIBITORS OF MATRIX METALLOPROTEINASE, FOR THERAPY OF DISEASES SUCH AS DEGENERATIVE DISEASES AND CERTAIN CANCERS | DARWIN DISCOVERY, LTD. (GB) | 2002-10-22 | — | — | US | claimed |
| US-20020013333-A1 | Hydroxamic and carboxylic acid derivatives | DARWIN DISCOVERY LIMITED (GB) | 2002-01-31 | — | — | US | claimed |
| WO-2001087883-A1 | HYDROXAMIC AND CARBOXYLIC ACID DERIVATIVES HAVING MMP AND TNF INHIBITORY ACTIVITY | DARWIN DISCOVERY LIMITED (GB) | 2001-11-22 | — | — | WO | claimed |
| US-20040176362-A1 | Hydroxamic and carboxylic acid derivatives | BATTY DUNCAN (GB) | 2004-09-09 | — | — | US | disclosed |
| US-6734189-B2 | TETRAHYDRO-N-CARBOXYALKYLSULFONYLCARBOLINE DERIVATIVES, USEFUL FOR THE TREATMENT OF DISEASES MEDIATED BY INHIBITORS OF MATRIX METALLOPROTEINASE, ADAM, ADAM-TS ENZYMES, AND/OR TNF ALPHA -MEDIATED DISEASES | DARWIN DISCOVERY, LTD. (GB) | 2004-05-11 | — | — | US | disclosed |
| EP-1286994-A1 | HYDROXAMIC AND CARBOXYLIC ACID DERIVATIVES HAVING MMP AND TNF INHIBITORY ACTIVITY | Darwin Discovery Limited (GB) | 2003-03-05 | — | — | EP | disclosed |
| US-6469020-B2 | AS INHIBITORS OF MATRIX METALLOPROTEINASE, FOR THERAPY OF DISEASES SUCH AS DEGENERATIVE DISEASES AND CERTAIN CANCERS | DARWIN DISCOVERY, LTD. (GB) | 2002-10-22 | — | — | US | disclosed |
| US-20020013333-A1 | Hydroxamic and carboxylic acid derivatives | DARWIN DISCOVERY LIMITED (GB) | 2002-01-31 | — | — | US | disclosed |
| WO-2001087883-A1 | HYDROXAMIC AND CARBOXYLIC ACID DERIVATIVES HAVING MMP AND TNF INHIBITORY ACTIVITY | DARWIN DISCOVERY LIMITED (GB) | 2001-11-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020013333-A1 | Hydroxamic and carboxylic acid derivatives | HCAR2, HCAR1, CBR1 | GPX4 3705/4885HDAC1 135/4885HDAC6 272/4885 |
| US-20040176362-A1 | Hydroxamic and carboxylic acid derivatives | ADAM17, ADAM10, ADAM9 | GPX4 3329/4885HDAC1 67/4885HDAC6 357/4885 |
| US-20030032652-A1 | Hydroxamic and carboxylic acid derivatives | ADAM17, ADAM10, ADAM9 | GPX4 3329/4885HDAC1 67/4885HDAC6 357/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.