SCHEMBL678428

SCHEMBL678428

CC(Cl)c1ccc(Cl)cc1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADRB2 P07550 1/20 0.59
TSHR P16473 4/20 0.55
HIF1A Q16665 4/20 0.55
MAPK1 P28482 3/20 0.55
TDP1 Q9NUW8 3/20 0.55
LMNA P02545 3/20 0.47
CYP2A6 P11509 1/20 0.47
TP53 P04637 1/20 0.46
HPGD P15428 1/20 0.46
BRD4 O60885 1/20 0.43
CYP19A1 P11511 3/20 0.42
IDO1 P14902 2/20 0.42
TDO2 P48775 2/20 0.42
FFAR2 O15552 1/20 0.42
SLC6A2 P23975 3/20 0.41
SLC6A3 Q01959 3/20 0.41
SLC6A4 P31645 2/20 0.40
CYP2C9 P11712 1/20 0.40
CYP2C19 P33261 1/20 0.40
KDM4E B2RXH2 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11621775 0.92 ADRB2 (0.52) ADRB2TSHRHIF1AMAPK1TDP1
SCHEMBL2865480 0.87 ADRB2 (0.41) ADRB2TSHRHIF1AMAPK1TDP1
SCHEMBL30471741 0.85 TYR (0.46) ADRB2TSHRHIF1AMAPK1TDP1
SCHEMBL8750387 0.85 TYR (0.46) ADRB2TSHRHIF1AMAPK1TDP1
SCHEMBL197810 0.81 ADRB2 (0.65) ADRB2TSHRHIF1AMAPK1TDP1
SCHEMBL1045498 0.80 ADRB2 (0.56) ADRB2TSHRHIF1AMAPK1TDP1
SCHEMBL30720007 0.79 ADRB2 (0.62) ADRB2TSHRHIF1AMAPK1TDP1
SCHEMBL4445207 0.79 ADRB2 (0.62) ADRB2TSHRHIF1AMAPK1TDP1
SCHEMBL153358 0.79 ADRB2 (0.62) ADRB2TSHRHIF1AMAPK1TDP1
Hydrochloric Acid SCHEMBL28767407 0.79 ADRB2 (0.62) ADRB2TSHRHIF1AMAPK1TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 70 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-11171804-A None JP disclosed
CN-122059820-A Method for synthesizing carboxylic acid compound by titanium catalysis 陕西师范大学 2026-05-19 CN disclosed
CN-122059950-A Compounds with proteasome agonistic activity, preparation method and application thereof 浙大城市学院 2026-05-19 CN disclosed
US-20230022091-A1 COMPOUND FUNCTIONING AS BROMODOMAIN PROTEIN INHIBITOR, AND COMPOSITION BETTA PHARMACEUTICALS CO., LTD. (CN) 2023-01-26 US disclosed
US-11466034-B2 Compound functioning as bromodomain protein inhibitor, and composition BETTA PHARMACEUTICALS CO., LTD. (CN) 2022-10-11 US disclosed
CN-115160101-A Synthetic method of (R) -1, 3-diaryl butene compound 南京工业大学 2022-10-11 CN disclosed
US-20200385408-A1 COMPOUND FUNCTIONING AS BROMODOMAIN PROTEIN INHIBITOR, AND COMPOSITION BETTA PHARMACEUTICALS CO., LTD. (CN) 2020-12-10 US disclosed
CN-107721886-B Preparation method of 1-aryl ethanesulfonic acid and derivatives thereof 河南新天地药业股份有限公司 2020-11-03 CN disclosed
EP-3719017-A2 COMPOUND FUNCTIONING AS BROMODOMAIN PROTEIN INHIBITOR, AND COMPOSITION Betta Pharmaceuticals Co., Ltd. (CN) 2020-10-07 EP disclosed
CN-110802101-A Method for manufacturing mould by recovering all components of wind power blade through two-step method 中国科学院山西煤炭化学研究所 2020-02-18 CN disclosed
EP-0705258-A1 AZOLYL-CYCLIC AMINE DERIVATIVES WITH IMMUNOMODULATORY ACTIVITY Knoll AG (DE) 1996-04-10 EP disclosed
WO-1995000507-A1 AZOLYL-CYCLIC AMINE DERIVATIVES WITH IMMUNOMODULATORY ACTIVITY KNOLL AG (DE) 1995-01-05 WO disclosed
US-4156602-A 1-(1-Chloropropyl)-2,4,6-triisopropylbenzene and its use to control weeds PPG INDUSTRIES, INC. (US) 1979-05-29 US disclosed
EP-0000019-A1 N-benzylcycloalkylamines and process for their preparation NIHON TOKUSHU NOYAKU SEIZO K.K. (JP) 1978-12-20 EP disclosed
US-4081596-A DIURETIC, SALURETIC, ANTIHYPERTENSIVE, ANTITHROMBOTIC BAYER AKTIENGESELLSCHAFT (DT) 1978-03-28 US disclosed
US-4019893-A Herbicidal method using 2-sulfinyl or 2-sulfonyl pyridine N-oxide derivatives UNIROYAL INC. (US) 1977-04-26 US disclosed
US-4005215-A DIURETIC BAYER AKTIENGESELLSCHAFT (DT) 1977-01-25 US disclosed
US-3978077-A DIURETIC, HYPOTENSIVE, ANTITHROMBOTIC BAYER AKTIENGESELLSCHAFT (GB) 1976-08-31 US disclosed
US-3960542-A Herbicidal 2-sulfinyl and 2-sulfonyl pyridine N-oxide derivatives UNIROYAL INC. (US) 1976-06-01 US disclosed
US-3957814-A DIURETICS, SALURETICS, HYPOTENSIVE AGENTS, ANTITHROMBOTIC BAYER AKTIENGESELLSCHAFT (DT) 1976-05-18 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11466034-B2 Compound functioning as bromodomain protein inhibitor, and composition BRD4, BRD1, BRD2 ADRB2 3998/4885TSHR 4320/4885HIF1A 4414/4885
US-20230022091-A1 COMPOUND FUNCTIONING AS BROMODOMAIN PROTEIN INHIBITOR, AND COMPOSITION BRD4, BRD1, BRD2 ADRB2 3998/4885TSHR 4320/4885HIF1A 4414/4885
US-20200385408-A1 COMPOUND FUNCTIONING AS BROMODOMAIN PROTEIN INHIBITOR, AND COMPOSITION BRD4, BRD1, BRD2 ADRB2 3998/4885TSHR 4320/4885HIF1A 4414/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.