Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SENP6 | Q9GZR1 | 7/20 | 0.56 |
| ▸ | SENP7 | Q9BQF6 | 6/20 | 0.56 |
| ▸ | MAPT | P10636 | 7/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.48 |
| ▸ | MEN1 | O00255 | 5/20 | 0.48 |
| ▸ | SENP8 | Q96LD8 | 5/20 | 0.48 |
| ▸ | RAB9A | P51151 | 5/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.48 |
| ▸ | CASP3 | P42574 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | APAF1 | O14727 | 3/20 | 0.43 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 5/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | NSD2 | O96028 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6784562 | 1.00 | SENP6 (0.56) | SENP6SENP7MAPTKMT2AMEN1 | |
| SCHEMBL7973961 | 0.85 | RAB9A (0.44) | SENP6SENP7MAPTKMT2AMEN1 | |
| SCHEMBL7973963 | 0.85 | RAB9A (0.44) | SENP6SENP7MAPTKMT2AMEN1 | |
| SCHEMBL6768929 | 0.79 | RAB9A (0.41) | SENP6SENP7MAPTKMT2AMEN1 | |
| SCHEMBL6768931 | 0.79 | RAB9A (0.41) | SENP6SENP7MAPTKMT2AMEN1 | |
| SCHEMBL7989236 | 0.74 | CYP1A2 (0.48) | MAPTKMT2AMEN1RAB9ASMN1; SMN2 | |
| SCHEMBL2647057 | 0.71 | ALDH1A1 (0.39) | SENP6SENP7MAPTKMT2AMEN1 | |
| SCHEMBL11279464 | 0.70 | RAB9A (0.72) | SENP6SENP7MAPTKMT2AMEN1 | |
| SCHEMBL11279469 | 0.70 | RAB9A (0.72) | SENP6SENP7MAPTKMT2AMEN1 | |
| SCHEMBL7987387 | 0.68 | NPC1 (0.40) | MAPTKMT2AMEN1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6699859-B1 | TREATMENT OF ANXIETY AND CONVULSIONS. | MERCK SHARP & DOHME LTD. (GB) | 2004-03-02 | — | — | US | disclosed |