Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 4/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.42 |
| ▸ | MIF | P14174 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6786095 | 0.86 | ESR1 (0.39) | ESR1ESR2LMNAALDH1A1CYP3A4 | |
| SCHEMBL6786562 | 0.86 | HSP90AA1 (0.40) | ESR1ESR2MAPTKMT2AMEN1 | |
| SCHEMBL6785959 | 0.84 | KIF11 (0.39) | ESR1ESR2TSHR | |
| SCHEMBL6785281 | 0.83 | ESR2 (0.40) | ESR1ESR2MAPK1MAPTLMNA | |
| SCHEMBL6787530 | 0.78 | ALDH1A1 (0.44) | KMT2AMEN1ALDH1A1RAB9A | |
| SCHEMBL6782115 | 0.77 | FFAR1 (0.37) | PPARA | |
| SCHEMBL11847736 | 0.72 | MIF (0.39) | MIFMAPTKMT2AMEN1CYP3A4 | |
| SCHEMBL10347288 | 0.71 | MIF (0.50) | MIFMAPK1MAPTKMT2ALMNA | |
| SCHEMBL6782872 | 0.70 | KMT2A (0.40) | ESR1MAPTKMT2ALMNAMEN1 | |
| SCHEMBL6785475 | 0.70 | KIF11 (0.38) | KMT2AMEN1ALDH1A1CYP2C19CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6825354-B2 | OSTEOPOROSIS; RHEUMATIC DISEASES | WYETH HOLDINGS CORPORATION | 2004-11-30 | — | — | US | disclosed |