Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB3 | P13945 | 15/20 | 0.56 |
| ▸ | ADRB1 | P08588 | 8/20 | 0.56 |
| ▸ | ADRB2 | P07550 | 6/20 | 0.56 |
| ▸ | PNP | P00491 | 2/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PPARD | Q03181 | 1/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7593268 | 0.90 | ADRB3 (0.46) | ADRB3ADRB1ADRB2CYP1A2CYP2C9 | |
| SCHEMBL7572345 | 0.83 | ADRB3 (0.40) | ADRB3ADRB1ADRB2PNP | |
| SCHEMBL7779180 | 0.76 | ADRB3 (0.72) | ADRB3ADRB1ADRB2 | |
| SCHEMBL5536670 | 0.75 | ADRB3 (0.48) | ADRB3ADRB1ADRB2ADRA1DADRA1A | |
| Rafabegron SCHEMBL7606623 | 0.72 | ADRB3 (1.00) | ADRB3ADRB1ADRB2ADRA1DADRA1A | |
| Rafabegron SCHEMBL3694097 | 0.72 | ADRB3 (1.00) | ADRB3ADRB1ADRB2ADRA1DADRA1A | |
| Rafabegron SCHEMBL678589 | 0.72 | ADRB3 (1.00) | ADRB3ADRB1ADRB2ADRA1DADRA1A | |
| Rafabegron SCHEMBL7865766 | 0.72 | ADRB3 (1.00) | ADRB3ADRB1ADRB2ADRA1DADRA1A | |
| Rafabegron SCHEMBL29361441 | 0.72 | ADRB3 (1.00) | ADRB3ADRB1ADRB2ADRA1DADRA1A | |
| Rafabegron SCHEMBL6910797 | 0.72 | ADRB3 (1.00) | ADRB3ADRB1ADRB2ADRA1DADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6458824-B1 | (3-((2R)-(((2R)-(3-CHLOROPHENYL)-2-HYDROXYETHYL)AMINO)PROPYL)-1H-INDOL-7-YLOXY)ACETIC ACID CRYSTAL SOLIDS | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 2002-10-01 | — | — | US | claimed |
| EP-1235801-A2 | SOLID PHARMACEUTICAL PREPARATION | Dainippon Pharmaceutical Co., Ltd. (JP) | 2002-09-04 | — | — | EP | claimed |
| WO-2001040182-A2 | SOLID PHARMACEUTICAL PREPARATION | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 2001-06-07 | — | — | WO | claimed |
| US-9238025-B2 | Transdermal preparation comprising a ropinirole derivative | HISAMITSU PHARMACEUTICAL CO., INC. (JP) | 2016-01-19 | — | — | US | disclosed |
| EP-2438917-B1 | TRANSDERMAL PREPARATION | HISAMITSU PHARMACEUTICAL CO (JP) | 2014-09-03 | — | — | EP | disclosed |
| US-20120052113-A1 | TRANSDERMAL PREPARATION | HISAMITSU PHARMACEUTICAL CO., INC. (JP) | 2012-03-01 | — | — | US | disclosed |
| US-20110269717-A1 | NEUROGENESIS BY MODULATING ANGIOTENSIN | BRAINCELLS INC. (US) | 2011-11-03 | — | — | US | disclosed |
| EP-2382975-A2 | Neurogenesis by modulating angiotensin | Braincells, Inc. (US) | 2011-11-02 | — | — | EP | disclosed |
| EP-2377530-A2 | Modulation of neurogenesis by PDE inhibition | Braincells, Inc. (US) | 2011-10-19 | — | — | EP | disclosed |
| EP-2377531-A2 | Neurogenesis by modulating angiotensin | Braincells, Inc. (US) | 2011-10-19 | — | — | EP | disclosed |
| US-7998971-B2 | 2-(2-oxopyrrolidin- 1 -yl)-N-(2,3 -dimethyl-5,6,7,8-tetrahydrofuro[2,3-b]quinolin-4-yl)acetoamide (MKC-231) and a second active ingredient for treating central or peripheral nervous system disorders increase neurogenesis; synergistic; drug addiction, psychological disorders, transplant rejection | BRAINCELLS INC. (US) | 2011-08-16 | — | — | US | disclosed |
| CN-1433403-A | Solid pharmaceutical preparation | DAINIPPON PHARMAECUTICAL CO LT (JP) | 2003-07-30 | — | — | CN | disclosed |
| JP-2002356423-A | ADHESIVE PREPARATION | DAINIPPON PHARMACEUT CO LTD | 2002-12-13 | — | — | JP | disclosed |
| US-6458824-B1 | (3-((2R)-(((2R)-(3-CHLOROPHENYL)-2-HYDROXYETHYL)AMINO)PROPYL)-1H-INDOL-7-YLOXY)ACETIC ACID CRYSTAL SOLIDS | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 2002-10-01 | — | — | US | disclosed |
| US-6458824-B1 | (3-((2R)-(((2R)-(3-CHLOROPHENYL)-2-HYDROXYETHYL)AMINO)PROPYL)-1H-INDOL-7-YLOXY)ACETIC ACID CRYSTAL SOLIDS | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 2002-10-01 | — | — | US | disclosed |
| EP-1235801-A2 | SOLID PHARMACEUTICAL PREPARATION | Dainippon Pharmaceutical Co., Ltd. (JP) | 2002-09-04 | — | — | EP | disclosed |
| EP-1235801-A2 | SOLID PHARMACEUTICAL PREPARATION | Dainippon Pharmaceutical Co., Ltd. (JP) | 2002-09-04 | — | — | EP | disclosed |
| WO-2001040182-A3 | SOLID PHARMACEUTICAL PREPARATION | DAINIPPON PHARMACEUTICAL CO (JP) | 2002-06-27 | — | — | WO | disclosed |
| WO-2001040182-A2 | SOLID PHARMACEUTICAL PREPARATION | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 2001-06-07 | — | — | WO | disclosed |
| WO-2001040182-A2 | SOLID PHARMACEUTICAL PREPARATION | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 2001-06-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110269717-A1 | NEUROGENESIS BY MODULATING ANGIOTENSIN | NGF, DCX, BDNF | ADRB3 293/4885ADRB1 386/4885ADRB2 542/4885 |
| US-20120052113-A1 | TRANSDERMAL PREPARATION | HTR3D, HTR5A, HTR1E | ADRB3 326/4885ADRB1 303/4885ADRB2 331/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.