Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.45 |
| ▸ | KAT2B | Q92831 | 2/20 | 0.45 |
| ▸ | BRD9 | Q9H8M2 | 2/20 | 0.45 |
| ▸ | BPTF | Q12830 | 2/20 | 0.45 |
| ▸ | AXL | P30530 | 2/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 2/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6787784 | 0.81 | NPC1 (0.53) | MAPTHPGDMAPK1MEN1KMT2A | |
| SCHEMBL6786104 | 0.77 | CYP3A4 (0.46) | BRD4KAT2BBRD9RORCMAPT | |
| SCHEMBL6785382 | 0.77 | RXFP1 (0.47) | MAPTMAPK1MEN1KMT2ACYP1A2 | |
| SCHEMBL6787760 | 0.77 | MAPT (0.43) | BPTFMAPTHPGDHSD17B10KDM4E | |
| SCHEMBL6785905 | 0.75 | ALDH1A1 (0.42) | MAPTHPGDKDM4EMEN1KMT2A | |
| SCHEMBL6781479 | 0.75 | RORC (0.41) | RORCMAPK1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL6781849 | 0.73 | PDE2A (0.38) | BRD4KAT2BRORCMAPTCYP3A4 | |
| SCHEMBL6784794 | 0.72 | CYP3A4 (0.46) | RORCMAPTHPGDHSD17B10MAPK1 | |
| SCHEMBL6786326 | 0.72 | PDE2A (0.42) | RORCMAPTHPGDHSD17B10MAPK1 | |
| SCHEMBL6786418 | 0.71 | MAP4K4 (0.44) | CDK2HSD17B10MAPK1CYP3A4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6686373-B2 | ANALGESICS; ANTIINFLAMMATORY AGENT | WARNER-LAMBERT COMPANY LLC | 2004-02-03 | — | — | US | disclosed |
| US-20030130277-A1 | Pyrazoloquinolinone derivatives as protein kinase C inhibitors | KAWAMURA KIYOSHI (JP) | 2003-07-10 | — | — | US | disclosed |
| EP-1310498-A2 | Pyrazoloquinolinone derivatives as protein kinase C inhibitors | PFIZER INC. (US) | 2003-05-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030130277-A1 | Pyrazoloquinolinone derivatives as protein kinase C inhibitors | PRKCB, PRKCA, PRKCG | BRD4 975/4885KAT2B 1869/4885BRD9 1552/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.