Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.43 |
| ▸ | RAB9A | P51151 | 6/20 | 0.43 |
| ▸ | NPC1 | O15118 | 5/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6790851 | 1.00 | SMN1; SMN2 (0.43) | SMN1; SMN2RAB9ANPC1USP2ALDH1A1 | |
| SCHEMBL6792267 | 0.78 | MTNR1A (0.38) | RAB9ANPC1ALDH1A1KMT2AMEN1 | |
| SCHEMBL6792263 | 0.78 | MTNR1A (0.38) | RAB9ANPC1ALDH1A1KMT2AMEN1 | |
| SCHEMBL14223693 | 0.77 | SMN1; SMN2 (0.47) | SMN1; SMN2RAB9ANPC1USP2ALDH1A1 | |
| SCHEMBL2949765 | 0.76 | SMN1; SMN2 (0.48) | SMN1; SMN2RAB9ANPC1USP2ALDH1A1 | |
| SCHEMBL2949763 | 0.76 | SMN1; SMN2 (0.48) | SMN1; SMN2RAB9ANPC1USP2ALDH1A1 | |
| SCHEMBL13503683 | 0.75 | SMN1; SMN2 (0.48) | SMN1; SMN2RAB9ANPC1USP2ALDH1A1 | |
| SCHEMBL6794137 | 0.74 | LMNA (0.46) | SMN1; SMN2RAB9ANPC1USP2ALDH1A1 | |
| SCHEMBL18719831 | 0.74 | SMN1; SMN2 (0.75) | SMN1; SMN2RAB9ANPC1USP2ALDH1A1 | |
| SCHEMBL22409405 | 0.71 | ALDH1A1 (0.39) | SMN1; SMN2RAB9ANPC1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6720338-B2 | BCL-X1 INHIBITING COMPOSITIONS AND METHODS OF PROMOTING APOPTOSIS IN A MAMMAL | ABBOTT LABORATORIES | 2004-04-13 | — | — | US | disclosed |