SCHEMBL6791649

SCHEMBL6791649

O=Cc1ccccc1Oc1cccc(C(F)(F)F)c1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 3/20 0.60
GAA P10253 2/20 0.60
KMT2A Q03164 1/20 0.60
NPSR1 Q6W5P4 3/20 0.53
ALDH1A1 P00352 4/20 0.52
L3MBTL1 Q9Y468 4/20 0.52
POLB P06746 2/20 0.52
CYP1A2 P05177 2/20 0.50
CYP2C9 P11712 2/20 0.50
CYP2C19 P33261 2/20 0.50
MAPT P10636 3/20 0.44
KDM4E B2RXH2 1/20 0.42
HPGD P15428 1/20 0.42
HTT P42858 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
RXFP1 Q9HBX9 1/20 0.42
ABCG2 Q9UNQ0 1/20 0.41
KIF11 P52732 1/20 0.41
ICAM1 P05362 1/20 0.41
SELE P16581 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL733917 0.88 NPSR1 (0.59) LMNAGAAKMT2ANPSR1ALDH1A1
SCHEMBL5322854 0.83 LMNA (0.66) LMNAGAAKMT2ANPSR1ALDH1A1
SCHEMBL6955863 0.82 LMNA (0.60) LMNAGAAKMT2ANPSR1ALDH1A1
SCHEMBL14661915 0.81 L3MBTL1 (0.49) LMNAKMT2ANPSR1ALDH1A1L3MBTL1
SCHEMBL4613870 0.80 LMNA (0.57) LMNAGAAKMT2ANPSR1ALDH1A1
SCHEMBL7138558 0.80 LMNA (0.57) LMNAGAAKMT2ANPSR1ALDH1A1
SCHEMBL2353958 0.80 LMNA (0.66) LMNAGAAKMT2ANPSR1ALDH1A1
SCHEMBL875821 0.78 POLB (0.51) ALDH1A1L3MBTL1POLBMAPTKDM4E
SCHEMBL1564078 0.78 POLB (0.51) ALDH1A1L3MBTL1POLBMAPTKDM4E
SCHEMBL1643641 0.77 L3MBTL1 (0.46) LMNAGAANPSR1ALDH1A1L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107641111-A A kind of synthetic method of xanthone and its derivative 浙江工业大学 2018-01-30 CN disclosed
US-20040058903-A1 Benzamide compounds as apo b secretion inhibitors FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2004-03-25 US disclosed
EP-1326835-A1 BENZAMIDE COMPOUNDS AS APO B SECRETION INHIBITORS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2003-07-16 EP disclosed
WO-2002028835-A1 BENZAMIDE COMPOUNDS AS APO B SECRETION INHIBITORS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2002-04-11 WO disclosed
US-6307068-B1 TREATING OR IN PREVENTING CANCER. ADIR ET COMPAGNIE (FR) 2001-10-23 US disclosed
EP-1086107-A1 ARTEMISININ DERIVATIVES, METHOD FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) 2001-03-28 EP disclosed
WO-1999065914-A1 ARTEMISININ DERIVATIVES, METHOD FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME SHANGHAI INSTITUTE OF MATERIA MEDICA (CN) 1999-12-23 WO disclosed
US-5931995-A Ink compositions XEROX CORPORATION (US) 1999-08-03 US disclosed
US-5744273-A Laminatable backing substrates containing fluoro compounds for improved toner flow XEROX CORPORATION (US) 1998-04-28 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040058903-A1 Benzamide compounds as apo b secretion inhibitors APOB, APOL1, SCARB1 LMNA 1239/4885GAA 977/4885KMT2A 2457/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.