Sugi Predict

Sugi Predict / Compounds / SCHEMBL679209

SCHEMBL679209

SCHEMBL679209

Cn1ncc2cc(Oc3ccc([N+](=O)[O-])cc3F)c(N=C(c3ccccc3)c3ccccc3)cc21

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 2/20 0.39
▸ MAPT P10636 2/20 0.39
▸ L3MBTL1 Q9Y468 2/20 0.39
▸ MAPK1 P28482 1/20 0.39
▸ HSPB1 P04792 4/20 0.39
▸ S1PR4 O95977 1/20 0.37
▸ GLS O94925 1/20 0.36
▸ ELANE P08246 2/20 0.35
▸ SERPINE1 P05121 1/20 0.35
▸ NPC1 O15118 1/20 0.35
▸ PTGDR2 Q9Y5Y4 1/20 0.34
▸ LMNA P02545 2/20 0.34
▸ KMT2A Q03164 2/20 0.34
▸ F2 P00734 1/20 0.34
▸ PLAU P00749 1/20 0.34
▸ KLKB1 P03952 1/20 0.34
▸ CTRB1 P17538 1/20 0.34
▸ SLC22A12 Q96S37 1/20 0.34
▸ PLK4 O00444 1/20 0.34
▸ NTRK1 P04629 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL679110 0.80 SERPINE1 (0.43) ALDH1A1MAPTL3MBTL1MAPK1HSPB1
SCHEMBL679255 0.79 HSPB1 (0.44) ALDH1A1MAPTL3MBTL1MAPK1HSPB1
SCHEMBL29487166 0.79 HSPB1 (0.44) ALDH1A1MAPTL3MBTL1MAPK1HSPB1
SCHEMBL679474 0.79 ALDH1A1 (0.44) ALDH1A1MAPTL3MBTL1MAPK1HSPB1
SCHEMBL679247 0.78 CYP11B1 (0.47) ALDH1A1MAPTL3MBTL1MAPK1HSPB1
SCHEMBL680514 0.76 PLK4 (0.41) ALDH1A1MAPTL3MBTL1MAPK1HSPB1
SCHEMBL23081442 0.76 CCNT1 (0.42) ALDH1A1MAPTL3MBTL1MAPK1HSPB1
SCHEMBL678989 0.75 MAPT (0.44) ALDH1A1MAPTL3MBTL1HSPB1S1PR4
SCHEMBL680355 0.75 PLK4 (0.53) ALDH1A1MAPTL3MBTL1MAPK1HSPB1
SCHEMBL680085 0.74 S1PR4 (0.44) ALDH1A1MAPTL3MBTL1MAPK1HSPB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-RE43878-E1 Amidophenoxyindazoles useful as inhibitors of c-Met ELI LILLY AND COMPANY (US) 2012-12-25 — — US disclosed
EP-2310382-B1 AMIDOPHENOXYINDAZOLES USEFUL AS INHIBITORS OF C-MET LILLY CO ELI (US) 2012-02-22 — — EP disclosed
US-8030302-B2 Amidophenoxyindazoles useful as inhibitors of c-Met ELI LILLY AND COMPANY (US) 2011-10-04 — — US disclosed
EP-2310382-A1 AMIDOPHENOXYINDAZOLES USEFUL AS INHIBITORS OF C-MET Eli Lilly & Company (US) 2011-04-20 — — EP disclosed
WO-2010011538-A1 AMIDOPHENOXYINDAZOLES USEFUL AS INHIBITORS OF C-MET ELI LILLY AND COMPANY (US) 2010-01-28 — — WO disclosed
US-20100022529-A1 AMIDOPHENOXYINDAZOLES USEFUL AS INHIBITORS OF C-MET ELI LILLY AND COMPANY 2010-01-28 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100022529-A1 AMIDOPHENOXYINDAZOLES USEFUL AS INHIBITORS OF C-MET MET, MYCBP, MYC ALDH1A1 1450/4885MAPT 4502/4885L3MBTL1 461/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.