Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | TDP2 | O95551 | 1/20 | 0.39 |
| ▸ | CASP6 | P55212 | 1/20 | 0.39 |
| ▸ | UBE2I | P63279 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.39 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.39 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL680403 | 0.88 | ALDH1A1 (0.45) | ALDH1A1HSD17B10NPC1RAB9AHTR3A | |
| SCHEMBL679238 | 0.86 | NPSR1 (0.46) | LMNAALDH1A1RAB9AMEN1KMT2A | |
| SCHEMBL1259421 | 0.79 | FPR2 (0.42) | LMNAALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL199491 | 0.78 | IGF1R (0.47) | ALDH1A1MEN1KMT2ASMN1; SMN2HTT | |
| SCHEMBL2676725 | 0.75 | HTR3A (0.47) | LMNACD274ALDH1A1CASP1CASP7 | |
| SCHEMBL680508 | 0.75 | HTT (0.40) | LMNAALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL681007 | 0.75 | KMT2A (0.45) | LMNAALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL367875 | 0.72 | FPR2 (0.52) | ALDH1A1HSD17B10MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL4463803 | 0.70 | GAA (0.48) | LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL4332386 | 0.70 | SMO (0.54) | LMNAALDH1A1SMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2310382-B1 | AMIDOPHENOXYINDAZOLES USEFUL AS INHIBITORS OF C-MET | LILLY CO ELI (US) | 2012-02-22 | — | — | EP | disclosed |