Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.47 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | HPGDS | O60760 | 1/20 | 0.36 |
| ▸ | CDC25B | P30305 | 2/20 | 0.35 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | PLAT | P00750 | 1/20 | 0.33 |
| ▸ | XPO1 | O14980 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6793099 | 0.80 | LMNA (0.36) | ALDH1A1HSD17B10HPGDMEN1KMT2A | |
| SCHEMBL6793129 | 0.80 | MEN1 (0.39) | ALDH1A1HSD17B10HPGDMEN1KMT2A | |
| SCHEMBL6794835 | 0.79 | OPRD1 (0.35) | ALDH1A1HSD17B10HPGDGAAKDM4E | |
| SCHEMBL6798581 | 0.77 | OPRM1 (0.33) | ALDH1A1HSD17B10HPGDMEN1KMT2A | |
| SCHEMBL6798186 | 0.76 | ALDH1A1 (0.38) | ALDH1A1HSD17B10HPGDMEN1KMT2A | |
| SCHEMBL6793946 | 0.76 | CCNA2 (0.37) | ALDH1A1HSD17B10HPGDMEN1KMT2A | |
| SCHEMBL6800269 | 0.76 | ALDH1A1 (0.38) | AURKAALDH1A1HSD17B10HPGDMEN1 | |
| SCHEMBL6798834 | 0.75 | DRD2 (0.36) | NPSR1KDM4EMAPT | |
| SCHEMBL6788857 | 0.74 | ALDH1A1 (0.36) | ALDH1A1HSD17B10HPGDMEN1KMT2A | |
| SCHEMBL6792173 | 0.72 | AURKA (0.52) | AURKAMAPK10RIPK1ALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040127492-A1 | Cyclic pyrazoles for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | PHARMACIA CORPORATION | 2004-07-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040127492-A1 | Cyclic pyrazoles for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | MKNK2, MAPKAPK2, MAP3K2 | AURKA 341/4885MAPK10 108/4885RIPK1 549/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.