Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 2/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.36 |
| ▸ | CDK2 | P24941 | 2/20 | 0.36 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.36 |
| ▸ | HTT | P42858 | 4/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.36 |
| ▸ | MMP1 | P03956 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
| ▸ | MMP14 | P50281 | 1/20 | 0.36 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 5/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6792946 | 0.90 | CCNA2 (0.37) | PTGESCCNA2CDK2CCNA1SMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL6797949 | 0.88 | PTGES (0.39) | PTGESCCNA2CDK2CCNA1HTR7 | |
| Trifluoroacetic Acid SCHEMBL6799124 | 0.87 | PTGES (0.40) | PTGESSMN1; SMN2HTTTSHRCYP1A2 | |
| Trifluoroacetic Acid SCHEMBL1655632 | 0.87 | LMNA (0.38) | CCNA2CDK2CCNA1SMN1; SMN2HTT | |
| Trifluoroacetic Acid SCHEMBL6787710 | 0.85 | PTGES (0.38) | PTGESCCNA2CDK2CCNA1LMNA | |
| Trifluoroacetic Acid SCHEMBL6792435 | 0.85 | PTGES (0.35) | PTGESCCNA2CDK2CCNA1 | |
| Trifluoroacetic Acid SCHEMBL1655186 | 0.83 | KDM4C (0.34) | CDK2CYP1A2CYP3A4CYP2C9CYP2C19 | |
| Trifluoroacetic Acid SCHEMBL6792947 | 0.82 | CYP1A2 (0.38) | CCNA2CDK2CCNA1CYP1A2CYP3A4 | |
| Trifluoroacetic Acid SCHEMBL6793121 | 0.81 | ALDH1A1 (0.40) | PTGESTSHRCYP2C9LMNAALDH1A1 | |
| SCHEMBL1655472 | 0.81 | SMN1; SMN2 (0.43) | SMN1; SMN2HTTTSHRTP53LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040127492-A1 | Cyclic pyrazoles for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | PHARMACIA CORPORATION | 2004-07-01 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040127492-A1 | Cyclic pyrazoles for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | MKNK2, MAPKAPK2, MAP3K2 | PTGES 1542/4885CCNA2 270/4885CDK2 29/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.