Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ALB | P02768 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | PTGES | O14684 | 3/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | FBP1 | P09467 | 5/20 | 0.33 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.33 |
| ▸ | KCNA1 | Q09470 | 1/20 | 0.32 |
| ▸ | KCNAB1 | Q14722 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6793127 | 0.89 | ALDH1A1 (0.39) | ALDH1A1LMNAALBCYP2C9TSHR | |
| Trifluoroacetic Acid SCHEMBL6792947 | 0.85 | CYP1A2 (0.38) | CYP2C9MEN1KMT2A | |
| Trifluoroacetic Acid SCHEMBL6791540 | 0.83 | CYP1A2 (0.34) | CYP2C9 | |
| Trifluoroacetic Acid SCHEMBL6793508 | 0.83 | CDK4 (0.33) | CYP2C9 | |
| Trifluoroacetic Acid SCHEMBL4267640 | 0.82 | CCNA2 (0.32) | ALDH1A1LMNAPTGESMEN1KMT2A | |
| Trifluoroacetic Acid SCHEMBL6799124 | 0.82 | PTGES (0.40) | ALDH1A1LMNATSHRTDP1PTGES | |
| Trifluoroacetic Acid SCHEMBL6795264 | 0.82 | NPC1 (0.39) | CYP2C9TSHRMEN1KMT2A | |
| Trifluoroacetic Acid SCHEMBL1655691 | 0.82 | CDK2 (0.32) | CYP2C9TSHR | |
| Trifluoroacetic Acid SCHEMBL6790792 | 0.82 | KDM4E (0.33) | ALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL6797949 | 0.81 | PTGES (0.39) | PTGES |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040127492-A1 | Cyclic pyrazoles for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | PHARMACIA CORPORATION | 2004-07-01 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040127492-A1 | Cyclic pyrazoles for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | MKNK2, MAPKAPK2, MAP3K2 | ALDH1A1 4449/4885LMNA 4286/4885ALB 4160/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.