Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | NAMPT | P43490 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6799128 | 0.89 | NAMPT (0.39) | POLBNAMPTMAPTADRB2ALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL6792940 | 0.87 | PTGES (0.39) | PTGESALDH1A1MEN1KMT2ACYP1A2 | |
| Trifluoroacetic Acid SCHEMBL6792435 | 0.86 | PTGES (0.35) | PTGES | |
| Trifluoroacetic Acid SCHEMBL6788878 | 0.84 | PTGES (0.33) | PTGESALDH1A1SMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL6787710 | 0.83 | PTGES (0.38) | PTGESPOLBALDH1A1LMNA | |
| Trifluoroacetic Acid SCHEMBL6793379 | 0.83 | SLC6A9 (0.35) | PTGESALDH1A1KMT2ALMNASMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL6793121 | 0.82 | ALDH1A1 (0.40) | PTGESALDH1A1MEN1KMT2ANPSR1 | |
| Trifluoroacetic Acid SCHEMBL6791540 | 0.81 | CYP1A2 (0.34) | POLBNAMPTCYP1A2CYP2C19KDM4E | |
| Trifluoroacetic Acid SCHEMBL6793644 | 0.81 | CDK2 (0.36) | ALDH1A1CYP1A2CYP2D6CYP2C19 | |
| Trifluoroacetic Acid SCHEMBL1656626 | 0.81 | CDK2 (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040127492-A1 | Cyclic pyrazoles for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | PHARMACIA CORPORATION | 2004-07-01 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040127492-A1 | Cyclic pyrazoles for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | MKNK2, MAPKAPK2, MAP3K2 | PTGES 1542/4885POLB 2849/4885NAMPT 658/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.