Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 6/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.36 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.36 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6789811 | 0.92 | KDM4E (0.42) | SMN1; SMN2KDM4EHPGDROCK2ROCK1 | |
| SCHEMBL6795180 | 0.92 | ROCK2 (0.40) | TACR1SMN1; SMN2HPGDLMNANPC1 | |
| SCHEMBL6794230 | 0.88 | ROCK2 (0.43) | TACR1ROCK2ROCK1SIRT2SIRT1 | |
| SCHEMBL6794591 | 0.87 | GRM2 (0.46) | TACR1LMNAROCK2ROCK1SIRT2 | |
| SCHEMBL6789047 | 0.86 | TACR1 (0.41) | TACR1ROCK2ROCK1SIRT2SIRT1 | |
| SCHEMBL6797973 | 0.86 | KDM4E (0.41) | TACR1SMN1; SMN2KDM4EROCK2ROCK1 | |
| SCHEMBL6794195 | 0.84 | ROCK2 (0.41) | TACR1KDM4EROCK2ROCK1ALDH1A1 | |
| SCHEMBL4513882 | 0.83 | ROCK2 (0.44) | TACR1ROCK2ROCK1SIRT2SIRT1 | |
| SCHEMBL6794050 | 0.82 | ROCK2 (0.44) | TACR1ROCK2ROCK1SIRT2SIRT1 | |
| SCHEMBL6794992 | 0.82 | TACR1 (0.40) | TACR1HPGDLMNAROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040058914-A1 | Combination drugs | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2004-03-25 | — | — | US | disclosed |
| US-20040023843-A1 | Preventives/remedies for emotional disorders | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2004-02-05 | — | — | US | disclosed |
| EP-1352659-A1 | COMBINATION DRUGS | Takeda Chemical Industries, Ltd. (JP) | 2003-10-15 | — | — | EP | disclosed |
| EP-1323429-A1 | PREVENTIVES/REMEDIES FOR EMOTIONAL DISORDERS | Takeda Chemical Industries, Ltd. (JP) | 2003-07-02 | — | — | EP | disclosed |
| EP-1145714-A1 | DRUGS | Takeda Chemical Industries, Ltd. (JP) | 2001-10-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040023843-A1 | Preventives/remedies for emotional disorders | MTNR1A, KISS1R, MTNR1B | TACR1 12/4885SMN1; SMN2 2817/4885KDM4E 2229/4885 |
| US-20040058914-A1 | Combination drugs | CHRNA1, CHRNA2, CHRM2 | TACR1 39/4885SMN1; SMN2 1564/4885KDM4E 2987/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.