Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | CACNA1G | O43497 | 5/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 4/20 | 0.45 |
| ▸ | DRD4 | P21917 | 2/20 | 0.45 |
| ▸ | HTR7 | P34969 | 5/20 | 0.45 |
| ▸ | HTR1A | P08908 | 4/20 | 0.45 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6791987 | 0.91 | GAA (0.47) | CACNA1GDRD2HTR1ADRD3 | |
| SCHEMBL6792965 | 0.85 | GAA (0.52) | CACNA1GMAPTHTR7HTR1AHTR2A | |
| SCHEMBL6789929 | 0.83 | MTTP (0.54) | MAPTDRD2DRD4HTR7HTR1A | |
| SCHEMBL6789349 | 0.82 | HTR7 (0.45) | DRD2DRD4HTR7HTR1AKCNH2 | |
| SCHEMBL6789329 | 0.82 | HTR1A (0.44) | DRD2DRD4HTR7HTR1AKCNH2 | |
| SCHEMBL6792604 | 0.81 | MTTP (0.53) | CACNA1GDRD2DRD4KCNH2ADRA1A | |
| SCHEMBL6792842 | 0.81 | DRD3 (0.46) | DRD2DRD4HTR7KCNH2ADRA1A | |
| SCHEMBL6794501 | 0.81 | HTR1A (0.49) | MAPTKMT2ADRD2HTR7HTR1A | |
| SCHEMBL6797449 | 0.80 | HTR2A (0.52) | DRD2HTR7HTR1AKCNH2ADRA1A | |
| SCHEMBL6790988 | 0.79 | DRD3 (0.46) | DRD2DRD4HTR7KCNH2ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6818644-B1 | FLUORENE-9-CARBOXYLIC AMIDES; INHIBITORS OF MICROSOMAL TRIGLYSERIDE-TRANSFER PROTEIN (MTP); ANTILIPEMIC AGENTS; ATHEROSCLEROSIS, DIABETES, EATING DISORDERS, AND PANCREATITIS | BOEHRINGER INGELHEIM PHARM GMBH & CO, KG (DE) | 2004-11-16 | — | — | US | disclosed |