Sugi Predict

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SCHEMBL6796967

SCHEMBL6796967

COc1ccc(-n2c(=O)n(O)c(=O)c3cc(F)c(N4CCCC4)nc32)cc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TRPV4 Q9HBA0 2/20 0.41
▸ ERCC5 P28715 1/20 0.40
▸ FEN1 P39748 1/20 0.40
▸ ALDH1A1 P00352 6/20 0.39
▸ MAPT P10636 5/20 0.39
▸ TP53 P04637 2/20 0.39
▸ LMNA P02545 2/20 0.39
▸ MITF O75030 1/20 0.39
▸ PKM P14618 1/20 0.39
▸ HPGD P15428 1/20 0.39
▸ HTT P42858 1/20 0.39
▸ RAB9A P51151 1/20 0.39
▸ KLF5 Q13887 1/20 0.39
▸ SMN1; SMN2 Q16637 1/20 0.39
▸ L3MBTL1 Q9Y468 1/20 0.39
▸ CRHR1 P34998 1/20 0.37
▸ GAA P10253 2/20 0.37
▸ USP2 O75604 4/20 0.37
▸ CYP1A2 P05177 4/20 0.37
▸ CYP3A4 P08684 4/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6801398 0.89 ALDH1A1 (0.37) FEN1ALDH1A1MAPTTP53LMNA
SCHEMBL6800863 0.88 FEN1 (0.38) FEN1ALDH1A1MAPTTP53LMNA
SCHEMBL6800342 0.84 TRPV4 (0.40) TRPV4FEN1LMNACRHR1CASP1
SCHEMBL6797050 0.81 ALDH1A1 (0.40) TRPV4ALDH1A1MAPTLMNAHPGD
SCHEMBL6801451 0.80 LMNA (0.39) FEN1ALDH1A1MAPTTP53LMNA
SCHEMBL6801982 0.79 THRB (0.42) TRPV4ERCC5FEN1ALDH1A1MAPT
SCHEMBL8287909 0.79 MAPT (0.44) ALDH1A1MAPTTP53LMNAMITF
SCHEMBL6801862 0.78 ALDH1A1 (0.39) ALDH1A1MAPTTP53LMNAHPGD
SCHEMBL6795621 0.78 KMT2A (0.42) ALDH1A1MAPTLMNAHPGDHTT
SCHEMBL6801438 0.75 LMNA (0.43) ALDH1A1MAPTLMNAHPGDRAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6825199-B2 7-Substituted quinazolin-2,4-diones useful as antibacterial agents WARNER-LAMBERT COMPANY 2004-11-30 — — US claimed
EP-1028950-B1 7-SUBSTITUTED QUINAZOLIN-2,4-DIONES USEFUL AS ANTIBACTERIAL AGENTS WARNER LAMBERT CO (US) 2003-05-02 — — EP claimed
US-20020115674-A1 Novel 7-substituted quinazolin-2,4-diones useful as antibacterial agents DOMAGALA JOHN MICHAEL (US) 2002-08-22 — — US claimed
US-6825199-B2 7-Substituted quinazolin-2,4-diones useful as antibacterial agents WARNER-LAMBERT COMPANY 2004-11-30 — — US disclosed
EP-1028950-B1 7-SUBSTITUTED QUINAZOLIN-2,4-DIONES USEFUL AS ANTIBACTERIAL AGENTS WARNER LAMBERT CO (US) 2003-05-02 — — EP disclosed
US-20020115674-A1 Novel 7-substituted quinazolin-2,4-diones useful as antibacterial agents DOMAGALA JOHN MICHAEL (US) 2002-08-22 — — US disclosed
US-6331538-B1 TREATMENT OF BACTERIAL INFECTION WARNER-LAMBERT COMPANY 2001-12-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020115674-A1 Novel 7-substituted quinazolin-2,4-diones useful as antibacterial agents NQO2, TOP1, TOP2A TRPV4 2869/4885ERCC5 1738/4885FEN1 2658/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.