Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 9/20 | 0.62 |
| ▸ | BCL2L1 | Q07817 | 7/20 | 0.62 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
| ▸ | GALK1 | P51570 | 1/20 | 0.49 |
| ▸ | CASP6 | P55212 | 1/20 | 0.49 |
| ▸ | PLEC | Q15149 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.49 |
| ▸ | PGR | P06401 | 1/20 | 0.48 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.48 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.48 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.47 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.47 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.46 |
| ▸ | MMP1 | P03956 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL680289 | 0.90 | MCL1 (0.70) | MCL1BCL2L1SCN9APGRSCN3A | |
| SCHEMBL680466 | 0.84 | EZH2 (0.54) | MCL1BCL2L1SCN9AHDAC8TDP1 | |
| SCHEMBL680286 | 0.84 | PGR (0.60) | MCL1BCL2L1SCN9APGR | |
| SCHEMBL678831 | 0.83 | BCL2L1 (0.52) | MCL1BCL2L1SCN9AHDAC8PGR | |
| SCHEMBL678903 | 0.83 | BCL2L1 (0.52) | MCL1BCL2L1SCN9AADORA3PGR | |
| SCHEMBL680849 | 0.82 | PTPN1 (0.52) | MCL1BCL2L1SCN9AHDAC8SCN3A | |
| SCHEMBL31331542 | 0.81 | SCN9A (0.64) | MCL1BCL2L1SCN9ASCN3A | |
| SCHEMBL679983 | 0.81 | ACACB (0.50) | MCL1BCL2L1SCN3A | |
| SCHEMBL679782 | 0.81 | SCN9A (0.50) | MCL1BCL2L1SCN9AHDAC8PGR | |
| SCHEMBL679146 | 0.81 | SCN9A (0.52) | MCL1BCL2L1SCN9ASCN3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593427-B1 | SULFONAMIDE DERIVATIVES AS NAV1.7 INHIBITORS FOR THE TREATMENT OF PAIN | PFIZER LTD (GB) | 2014-12-24 | — | — | EP | disclosed |
| US-20120010207-A1 | Chemical Compounds | PFIZER LIMITED (GB) | 2012-01-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120010207-A1 | Chemical Compounds | SCN1A, SCN1B, SCN7A | MCL1 2739/4885BCL2L1 3284/4885SCN9A 13/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.