Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTNNB1 | P35222 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | CA1 | P00915 | 2/20 | 0.31 |
| ▸ | CA2 | P00918 | 2/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA4 | P22748 | 1/20 | 0.31 |
| ▸ | CA7 | P43166 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.31 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1495183 | 0.80 | POLB (0.35) | GAAPOLBPTGDR2CA1CA2 | |
| SCHEMBL9166410 | 0.80 | GAA (0.39) | GAAPOLBPTGDR2CA1CA2 | |
| SCHEMBL1168428 | 0.78 | CA12 (0.32) | GAAPOLBPTGDR2CA1CA2 | |
| SCHEMBL95237 | 0.77 | GAA (0.48) | CTNNB1GAAPOLBMAPK1TSHR | |
| SCHEMBL97524 | 0.76 | CA1 (0.55) | GAAPOLBSMN1; SMN2CA1CA2 | |
| SCHEMBL10716261 | 0.76 | GAA (0.55) | GAAPOLBSMN1; SMN2NPC1RAB9A | |
| SCHEMBL13860241 | 0.76 | CA12 (0.31) | CA1CA2CA12CA4CA7 | |
| SCHEMBL10420902 | 0.76 | PTGDR2 (0.40) | GAAPTGDR2SMN1; SMN2NPC1RAB9A | |
| SCHEMBL744605 | 0.74 | PTGS2 (0.53) | MAPK1TSHR | |
| SCHEMBL887945 | 0.74 | GAA (0.46) | CTNNB1GAAPOLBMAPK1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6743794-B2 | MULTIDRUG RESISTANCE PROTEIN; CANCER; 3-(9-CHLORO-3-METHYL-4-OXO-5H-ISOXAZOLO(4,3-C)QUINOLIN-5-YL)) CYCLOHEXYL)-2-PIPERIDYLACETAMIDE | ELI LILLY AND COMPANY | 2004-06-01 | — | — | US | disclosed |
| EP-0486386-B1 | Novel derivatives of N-benzoylproline, process for their preparation and drugs containing them | ADIR (FR) | 1996-07-17 | — | — | EP | disclosed |
| EP-0486386-A2 | Novel derivatives of N-benzoylproline, process for their preparation and drugs containing them | ADIR ET COMPAGNIE (FR) | 1992-05-20 | — | — | EP | disclosed |
| EP-0175535-B1 | MAGNETIC COMPOSITE | POLYPLASTICS CO. LTD. (JP) | 1990-08-01 | — | — | EP | disclosed |
| US-4626371-A | ANISOTROPIC POLYMERS | CELANESE CORPORATION (US) | 1986-12-02 | — | — | US | disclosed |
| EP-0175535-A1 | Magnetic composite | POLYPLASTICS CO. LTD. (JP) | 1986-03-26 | — | — | EP | disclosed |
| EP-0125079-A2 | Process for extruding thermotropic liquid crystalline polymers | CELANESE CORPORATION (US) | 1984-11-14 | — | — | EP | disclosed |
| US-4468364-A | FORMING SHAPED ARTICLES FROM MELTS | CELANESE CORPORATION (US) | 1984-08-28 | — | — | US | disclosed |