Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HSPB1 | P04792 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL680888 | 0.93 | ATR (0.36) | ALDH1A1GAASMN1; SMN2LMNAS1PR4 | |
| SCHEMBL679716 | 0.93 | ATR (0.36) | ALDH1A1GAASMN1; SMN2LMNAS1PR4 | |
| SCHEMBL680364 | 0.87 | KDM4E (0.35) | HTTKDM4ERAB9A | |
| SCHEMBL679194 | 0.86 | RAB9A (0.32) | ALDH1A1S1PR4HSPB1MAPTRAB9A | |
| SCHEMBL680388 | 0.84 | HSPB1 (0.36) | ALDH1A1SMN1; SMN2S1PR4HSPB1MAPT | |
| SCHEMBL679444 | 0.84 | HSPB1 (0.36) | ALDH1A1SMN1; SMN2S1PR4HSPB1MAPT | |
| SCHEMBL679312 | 0.79 | ATR (0.37) | — | |
| SCHEMBL680593 | 0.74 | AXL (0.37) | ALDH1A1GAASMN1; SMN2KDM4EMAPT | |
| SCHEMBL1141432 | 0.74 | RAB9A (0.44) | ALDH1A1SMN1; SMN2LMNAMAPTRAB9A | |
| SCHEMBL680569 | 0.73 | LATS1 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2310382-B1 | AMIDOPHENOXYINDAZOLES USEFUL AS INHIBITORS OF C-MET | LILLY CO ELI (US) | 2012-02-22 | — | — | EP | disclosed |