Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | AXL | P30530 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL679311 | 0.92 | ATR (0.37) | AXL | |
| SCHEMBL679312 | 0.92 | ATR (0.37) | AXL | |
| SCHEMBL680593 | 0.87 | AXL (0.37) | KDM4ENPC1RAB9AAXL | |
| SCHEMBL680000 | 0.87 | ALDH1A1 (0.41) | KDM4EHTTRAB9A | |
| SCHEMBL680569 | 0.84 | LATS1 (0.33) | AXL | |
| SCHEMBL680525 | 0.83 | SCN9A (0.32) | NPC1RAB9AAXL | |
| SCHEMBL680888 | 0.79 | ATR (0.36) | RAB9AKMT2A | |
| SCHEMBL679716 | 0.79 | ATR (0.36) | RAB9AKMT2A | |
| SCHEMBL679194 | 0.72 | RAB9A (0.32) | RAB9A | |
| SCHEMBL1547818 | 0.71 | ATM (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2310382-B1 | AMIDOPHENOXYINDAZOLES USEFUL AS INHIBITORS OF C-MET | LILLY CO ELI (US) | 2012-02-22 | — | — | EP | disclosed |