Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | ATR | Q13535 | 9/20 | 0.32 |
| ▸ | FLT3 | P36888 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.31 |
| ▸ | EHMT1 | Q9H9B1 | 1/20 | 0.31 |
| ▸ | RAF1 | P04049 | 1/20 | 0.31 |
| ▸ | BRAF | P15056 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL679311 | 0.89 | ATR (0.37) | AXLATRBRAF | |
| SCHEMBL679312 | 0.89 | ATR (0.37) | AXLATRBRAF | |
| SCHEMBL680569 | 0.88 | LATS1 (0.33) | AXL | |
| SCHEMBL680364 | 0.87 | KDM4E (0.35) | AXLKDM4ENPC1RAB9A | |
| SCHEMBL680525 | 0.85 | SCN9A (0.32) | AXLSMN1; SMN2ALDH1A1NPC1RAB9A | |
| SCHEMBL679716 | 0.76 | ATR (0.36) | GAAMAPTSMN1; SMN2ATRALDH1A1 | |
| SCHEMBL680888 | 0.76 | ATR (0.36) | GAAMAPTSMN1; SMN2ATRALDH1A1 | |
| SCHEMBL679194 | 0.76 | RAB9A (0.32) | MAPTALDH1A1NPSR1RAB9A | |
| SCHEMBL680000 | 0.74 | ALDH1A1 (0.41) | GAAMAPTSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL31600834 | 0.71 | ABL1 (0.35) | GAAMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2310382-B1 | AMIDOPHENOXYINDAZOLES USEFUL AS INHIBITORS OF C-MET | LILLY CO ELI (US) | 2012-02-22 | — | — | EP | disclosed |