Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 2/20 | 0.36 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MITF | O75030 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.32 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | AKT1 | P31749 | 1/20 | 0.31 |
| ▸ | BRAF | P15056 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL680888 | 1.00 | ATR (0.36) | ATRFFAR2ALDH1A1MAPTLMNA | |
| SCHEMBL680000 | 0.93 | ALDH1A1 (0.41) | ALDH1A1MAPTLMNAGAASMN1; SMN2 | |
| SCHEMBL679194 | 0.88 | RAB9A (0.32) | ALDH1A1MAPTMITFRAB9AS1PR4 | |
| SCHEMBL679311 | 0.87 | ATR (0.37) | ATRFFAR2AKT1BRAFKDR | |
| SCHEMBL679312 | 0.87 | ATR (0.37) | ATRFFAR2AKT1BRAFKDR | |
| SCHEMBL680388 | 0.83 | HSPB1 (0.36) | ALDH1A1MAPTSMN1; SMN2RAB9AS1PR4 | |
| SCHEMBL679444 | 0.83 | HSPB1 (0.36) | ALDH1A1MAPTSMN1; SMN2RAB9AS1PR4 | |
| SCHEMBL680364 | 0.79 | KDM4E (0.35) | RAB9AKMT2A | |
| SCHEMBL1547818 | 0.78 | ATM (0.32) | ATRAKT1ATM | |
| SCHEMBL680593 | 0.76 | AXL (0.37) | ATRALDH1A1MAPTGAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2310382-B1 | AMIDOPHENOXYINDAZOLES USEFUL AS INHIBITORS OF C-MET | LILLY CO ELI (US) | 2012-02-22 | — | — | EP | disclosed |