Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 7/20 | 0.43 |
| ▸ | DRD3 | P35462 | 7/20 | 0.43 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.40 |
| ▸ | ITGAV | P06756 | 1/20 | 0.40 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.40 |
| ▸ | CASR | P41180 | 3/20 | 0.40 |
| ▸ | HPGDS | O60760 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 3/20 | 0.38 |
| ▸ | JAK1 | P23458 | 2/20 | 0.38 |
| ▸ | JAK3 | P52333 | 2/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | CTSL | P07711 | 1/20 | 0.38 |
| ▸ | CTSB | P07858 | 1/20 | 0.38 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL383009 | 0.88 | DRD2 (0.42) | DRD2DRD3ITGB3ITGAVITGA2B | |
| SCHEMBL6801474 | 0.85 | DRD2 (0.41) | DRD2DRD3ITGB3ITGAVITGA2B | |
| SCHEMBL6797887 | 0.84 | RAB9A (0.54) | KDM4ELMNAMAPTALDH1A1GFER | |
| SCHEMBL383161 | 0.82 | ITGB3 (0.47) | DRD2DRD3ITGB3ITGAVITGA2B | |
| SCHEMBL382447 | 0.81 | ITGB3 (0.48) | DRD2DRD3ITGB3ITGAVITGA2B | |
| SCHEMBL6800344 | 0.81 | DRD2 (0.43) | DRD2DRD3ITGB3ITGAVITGA2B | |
| SCHEMBL423056 | 0.80 | ITGB3 (0.40) | DRD2DRD3ITGB3ITGAVITGA2B | |
| SCHEMBL6799981 | 0.80 | DRD2 (0.40) | DRD2DRD3ITGB3ITGAVITGA2B | |
| SCHEMBL381721 | 0.80 | ITGB3 (0.40) | DRD2DRD3ITGB3ITGAVITGA2B | |
| SCHEMBL381767 | 0.79 | ITGB3 (0.51) | DRD2DRD3ITGB3ITGAVITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6750219-B1 | HAVING INTEGRIN ALPHA V BETA 3 ANTAGONISTIC ACTIVITY, GP IIB/IIIA ANTAGONISTIC ACTIVITY, AND/OR HUMAN PLATELET AGGREGATION INHIBITORY ACTIVITY AND ALSO HAVING EXCELLENT WATER SOLUBILITY | MEIJI SEIKA KAISHA, LTD. (JP) | 2004-06-15 | — | — | US | claimed |
| US-6750219-B1 | HAVING INTEGRIN ALPHA V BETA 3 ANTAGONISTIC ACTIVITY, GP IIB/IIIA ANTAGONISTIC ACTIVITY, AND/OR HUMAN PLATELET AGGREGATION INHIBITORY ACTIVITY AND ALSO HAVING EXCELLENT WATER SOLUBILITY | MEIJI SEIKA KAISHA, LTD. (JP) | 2004-06-15 | — | — | US | disclosed |