SCHEMBL6801574

SCHEMBL6801574

O=C(Nc1ccc2c(c1)CCN2)c1ccccc1-c1cccc(C(F)(F)F)c1

nearest known ligand 0.49

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
APOB P04114 7/20 0.49
MTTP P55157 6/20 0.49
RXFP1 Q9HBX9 10/20 0.48
PARP10 Q53GL7 1/20 0.47
PARP11 Q9NR21 1/20 0.47
P2RX1 P51575 1/20 0.47
PTGS1 P23219 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6645543 0.90 MTTP (0.61) APOBMTTPPTGS1
Hydrochloric Acid SCHEMBL6803931 0.89 MTTP (0.60) APOBMTTP
SCHEMBL6665641 0.87 APOB (0.51) APOBMTTPRXFP1PARP10PARP11
Hydrochloric Acid SCHEMBL6662670 0.86 APOB (0.50) APOBMTTPRXFP1PARP10PARP11
SCHEMBL6662843 0.80 SLC2A1 (0.49) APOBMTTP
SCHEMBL6804465 0.80 L3MBTL1 (0.52) APOBMTTP
Hydrochloric Acid SCHEMBL6803617 0.79 L3MBTL1 (0.51) APOBMTTP
SCHEMBL6665956 0.79 RXFP1 (0.41) APOBMTTPRXFP1PTGS1
SCHEMBL6803364 0.78 GAA (0.61) APOBMTTP
SCHEMBL6803896 0.77 APOB (0.51) APOBMTTP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20040157866-A1 Amide compounds FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2004-08-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040157866-A1 Amide compounds APOB, NR1H2, NR1H3 APOB 1/4885MTTP 108/4885RXFP1 411/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.