Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.42 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 5/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.38 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.38 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.38 |
| ▸ | NSD1 | Q96L73 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | CES2 | O00748 | 1/20 | 0.32 |
| ▸ | GALR3 | O60755 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29375214 | 0.86 | CYP3A4 (0.38) | CYP3A4TSHRTDP1ERCC1ERCC4 | |
| SCHEMBL189947 | 0.86 | CYP3A4 (0.38) | CYP3A4TSHRTDP1ERCC1ERCC4 | |
| SCHEMBL18241199 | 0.82 | ALOX15 (0.36) | CYP3A4TSHRTDP1ERCC1ERCC4 | |
| SCHEMBL16929987 | 0.82 | NMT1 (0.35) | CYP3A4TSHRTDP1ERCC1ERCC4 | |
| SCHEMBL25337641 | 0.78 | KDM1A (0.33) | CYP3A4TSHRTDP1ALOX15ALOX12 | |
| SCHEMBL29490989 | 0.78 | KDM1A (0.33) | CYP3A4TSHRTDP1ALOX15ALOX12 | |
| SCHEMBL2050124 | 0.77 | CYP3A4 (0.46) | CYP3A4TSHRTDP1ERCC1ERCC4 | |
| SCHEMBL22466232 | 0.77 | ERN1 (0.46) | ALOX15ALOX12ERN1 | |
| SCHEMBL25340705 | 0.77 | AKR1C3 (0.53) | CYP3A4TSHRTDP1ALOX15HPGD | |
| SCHEMBL30881823 | 0.77 | ESR1 (0.37) | CYP3A4TSHRTDP1GABRA1GABRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3046902-B1 | COMPOSITIONS FOR THE TREATMENT OF HYPERTENSION AND/OR FIBROSIS | VECTUS BIOSYSTEMS LTD (AU) | 2018-08-08 | — | — | EP | disclosed |
| US-9630935-B2 | Compositions for the treatment of hypertension and/or fibrosis | VECTUS BIOSYSTEMS LIMITED (AU) | 2017-04-25 | — | — | US | disclosed |
| US-20160280671-A1 | COMPOSITIONS FOR THE TREATMENT OF HYPERTENSION AND/OR FIBROSIS | VECTUS BIOSYSTEMS LIMITED (AU) | 2016-09-29 | — | — | US | disclosed |
| EP-3046902-A1 | COMPOSITIONS FOR THE TREATMENT OF HYPERTENSION AND/OR FIBROSIS | Vectus Biosystems Limited (AU) | 2016-07-27 | — | — | EP | disclosed |
| WO-2015039172-A1 | COMPOSITIONS FOR THE TREATMENT OF HYPERTENSION AND/OR FIBROSIS | VECTUS BIOSYSTEMS PTY LTD (AU) | 2015-03-26 | — | — | WO | disclosed |
| US-6828466-B2 | Reacting arene with borane; oxidation, hydrogenation phenylboronic acid | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY | 2004-12-07 | — | — | US | disclosed |
| US-20040030197-A1 | Process for the synthesis of phenols from arenes | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY | 2004-02-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160280671-A1 | COMPOSITIONS FOR THE TREATMENT OF HYPERTENSION AND/OR FIBROSIS | TGFB1, REN, TGFB2 | CYP3A4 4276/4885TSHR 3566/4885TDP1 4229/4885 |
| US-20040030197-A1 | Process for the synthesis of phenols from arenes | GRHPR, CBR1, CBR3 | CYP3A4 280/4885TSHR 55/4885TDP1 4468/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.