Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Aminorex. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A known ✓ | Q03164 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.41 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aminorex SCHEMBL123039 | 0.87 | TSHR (0.45) | HDAC3HDAC1HDAC2NCOR2HDAC8 | |
| SCHEMBL31158568 | 0.70 | TSHR (0.50) | HDAC3HDAC1HDAC2NCOR2HDAC8 | |
| SCHEMBL34460861 | 0.70 | TSHR (0.50) | HDAC3HDAC1HDAC2NCOR2HDAC8 | |
| Clominorex SCHEMBL121090 | 0.70 | TAAR1 (0.46) | RAB9ASLC6A3SMN1; SMN2TAAR1 | |
| SCHEMBL27806570 | 0.68 | HDAC3 (0.41) | HDAC3HDAC1HDAC2NCOR2HDAC8 | |
| SCHEMBL27848552 | 0.68 | HDAC3 (0.41) | HDAC3HDAC1HDAC2NCOR2HDAC8 | |
| SCHEMBL14301430 | 0.66 | TSHR (0.45) | SMN1; SMN2KDM4ETSHRHSD17B10ALDH1A1 | |
| SCHEMBL1548278 | 0.66 | ALDH1A1 (0.54) | KMT2ASMN1; SMN2KDM4ETSHRHSD17B10 | |
| SCHEMBL2399688 | 0.66 | TSHR (0.45) | SMN1; SMN2KDM4ETSHRHSD17B10ALDH1A1 | |
| SCHEMBL11748610 | 0.66 | TSHR (0.41) | HDAC3HDAC1HDAC2NCOR2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040038890-A1 | Human voltage-gated potassium channel subunit | AIYAR JAYASHREE (US) | 2004-02-26 | — | — | US | disclosed |
| WO-1999058666-A1 | POTASSIUM CHANNEL SUBUNIT | ASTRAZENECA AB (SE) | 1999-11-18 | — | — | WO | disclosed |
| WO-1999055331-A1 | USE OF ALPHA LIPOIC ACID TO REDUCE APPETITE AND/OR BODY WEIGHT | SKW TROSTBERG AKTIENGESELLSCHAFT (DE) | 1999-11-04 | — | — | WO | disclosed |