SCHEMBL11748610

SCHEMBL11748610

C=CC1=NCC(c2ccccc2)O1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.41
ALDH1A1 P00352 2/20 0.36
HPGD P15428 1/20 0.36
ATM Q13315 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
ADRA2A P08913 5/20 0.34
KDM4E B2RXH2 1/20 0.34
ADORA3 P0DMS8 1/20 0.34
AR P10275 1/20 0.34
CYP19A1 P11511 1/20 0.34
MAOB P27338 1/20 0.34
HSD17B10 Q99714 1/20 0.34
P2RY1 P47900 1/20 0.33
HDAC3 O15379 2/20 0.32
HDAC1 Q13547 2/20 0.32
HDAC2 Q92769 2/20 0.32
NCOR2 Q9Y618 2/20 0.32
HDAC8 Q9BY41 1/20 0.32
SLC6A2 P23975 1/20 0.32
SLC6A4 P31645 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL34460861 0.77 TSHR (0.50) TSHRALDH1A1HPGDATMSMN1; SMN2
SCHEMBL31158568 0.77 TSHR (0.50) TSHRALDH1A1HPGDATMSMN1; SMN2
SCHEMBL14301430 0.72 TSHR (0.45) TSHRALDH1A1HPGDATMSMN1; SMN2
SCHEMBL1548278 0.72 ALDH1A1 (0.54) TSHRALDH1A1HPGDATMSMN1; SMN2
Aminorex SCHEMBL123039 0.72 TSHR (0.45) TSHRALDH1A1HPGDATMSMN1; SMN2
SCHEMBL2399688 0.72 TSHR (0.45) TSHRALDH1A1HPGDATMSMN1; SMN2
SCHEMBL11342890 0.69 P2RY1 (0.35) TSHRALDH1A1HPGDATMSMN1; SMN2
SCHEMBL21772749 0.69 TSHR (0.38) TSHRALDH1A1HPGDATMSMN1; SMN2
SCHEMBL5395444 0.69 TSHR (0.38) TSHRALDH1A1HPGDATMSMN1; SMN2
SCHEMBL25416430 0.68 IMPDH2 (0.41) TSHRALDH1A1HPGDSMN1; SMN2KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220008313-A1 COSMETIC COMPOSITIONS CONTAINING OXAZOLINE FUNCTIONALIZED POLYMERS AND POLYAMINE COMPOUNDS L'OREAL (FR) 2022-01-13 US disclosed
US-11166904-B2 Cosmetic compositions containing oxazoline functionalized polymers and carboxyl group-containing polymers L'OREAL (FR) 2021-11-09 US disclosed
US-11154488-B2 Cosmetic compositions containing oxazoline functionalized polymers and amino silicone compounds L'OREAL (FR) 2021-10-26 US disclosed
US-11135151-B2 Cosmetic compositions containing oxazoline functionalized polymers and compound having at least one nucleophilic site capable of reacting with the at least one oxazoline functionalized compounds L'OREAL (FR) 2021-10-05 US disclosed
US-11129787-B2 Cosmetic compositions containing oxazoline functionalized polymers and polyamine compounds L'OREAL (FR) 2021-09-28 US disclosed
US-20200069556-A1 COSMETIC COMPOSITIONS CONTAINING OXAZOLINE FUNCTIONALIZED POLYMERS AND AMINO SILICONE COMPOUNDS L'OREAL (FR) 2020-03-05 US disclosed
US-20200069555-A1 COSMETIC COMPOSITIONS CONTAINING OXAZOLINE FUNCTIONALIZED POLYMERS AND POLYAMINE COMPOUNDS L'OREAL (FR) 2020-03-05 US disclosed
US-20200069559-A1 COSMETIC COMPOSITIONS CONTAINING OXAZOLINE FUNCTIONALIZED POLYMERS AND COMPOUND HAVING AT LEAST ONE NUCLEOPHILIC SITE CAPABLE OF REACTING WITH THE AT LEAST ONE OXAZOLINE FUNCTIONALIZED COMPOUNDS L'OREAL (FR) 2020-03-05 US disclosed
US-20200069557-A1 COSMETIC COMPOSITIONS CONTAINING OXAZOLINE FUNCTIONALIZED POLYMERS AND CARBOXYL GROUP-CONTAINING POLYMERS L'OREAL (FR) 2020-03-05 US disclosed
US-4045447-A COMONOMER FOR THERMOSETTING ACRYLIC COATINGS BAYER AKTIENGESELLSCHAFT (DT) 1977-08-30 US disclosed
US-3962270-A HEATING, CYCLOBUTANE-1,2-DINITRILE, AMINOETHANOL BAYER AKTIENGESELLSCHAFT (DT) 1976-06-08 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11135151-B2 Cosmetic compositions containing oxazoline functionalized polymers and compound having at least one nucleophilic site capable of reacting with the at least one oxazoline functionalized compounds KRT18, CUTA, PRKDC TSHR 4271/4885ALDH1A1 519/4885HPGD 1457/4885
US-11166904-B2 Cosmetic compositions containing oxazoline functionalized polymers and carboxyl group-containing polymers KRT18, CUTA, HDAC7 TSHR 4496/4885ALDH1A1 497/4885HPGD 958/4885
US-20200069556-A1 COSMETIC COMPOSITIONS CONTAINING OXAZOLINE FUNCTIONALIZED POLYMERS AND AMINO SILICONE COMPOUNDS KRT18, CUTA, LAGE3 TSHR 3999/4885ALDH1A1 2341/4885HPGD 2562/4885
US-20200069557-A1 COSMETIC COMPOSITIONS CONTAINING OXAZOLINE FUNCTIONALIZED POLYMERS AND CARBOXYL GROUP-CONTAINING POLYMERS KRT18, CUTA, HDAC7 TSHR 4496/4885ALDH1A1 497/4885HPGD 958/4885
US-20200069555-A1 COSMETIC COMPOSITIONS CONTAINING OXAZOLINE FUNCTIONALIZED POLYMERS AND POLYAMINE COMPOUNDS SRM, KRT18, ODC1 TSHR 4075/4885ALDH1A1 973/4885HPGD 1650/4885
US-11129787-B2 Cosmetic compositions containing oxazoline functionalized polymers and polyamine compounds SRM, KRT18, ODC1 TSHR 4075/4885ALDH1A1 973/4885HPGD 1650/4885
US-20220008313-A1 COSMETIC COMPOSITIONS CONTAINING OXAZOLINE FUNCTIONALIZED POLYMERS AND POLYAMINE COMPOUNDS SRM, KRT18, ODC1 TSHR 4075/4885ALDH1A1 973/4885HPGD 1650/4885
US-20200069559-A1 COSMETIC COMPOSITIONS CONTAINING OXAZOLINE FUNCTIONALIZED POLYMERS AND COMPOUND HAVING AT LEAST ONE NUCLEOPHILIC SITE CAPABLE OF REACTING WITH THE AT LEAST ONE OXAZOLINE FUNCTIONALIZED COMPOUNDS KRT18, CUTA, PRKDC TSHR 4271/4885ALDH1A1 519/4885HPGD 1457/4885
US-11154488-B2 Cosmetic compositions containing oxazoline functionalized polymers and amino silicone compounds KRT18, CUTA, LAGE3 TSHR 3999/4885ALDH1A1 2341/4885HPGD 2562/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.