Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPME1 | Q9Y570 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 2/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 3/20 | 0.34 |
| ▸ | SPR | P35270 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 6/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6804341 | 0.86 | PARP1 (0.51) | PARP1PRKD3ROCK1PRKD2DHODH | |
| SCHEMBL6810148 | 0.80 | MET (0.46) | PARP1ALDH1A1 | |
| SCHEMBL6586478 | 0.77 | PPME1 (0.40) | PPME1PARP1DHODH | |
| SCHEMBL16970998 | 0.68 | PARP1 (0.41) | PARP1MAPTDHODH | |
| SCHEMBL6809771 | 0.68 | TGFBR1 (0.39) | PARP1KDM4ENPSR1ROCK1 | |
| SCHEMBL6810142 | 0.66 | PARP1 (0.53) | PARP1PRKD3ROCK1PRKD2DHODH | |
| SCHEMBL6806425 | 0.65 | PARP1 (0.45) | PARP1KDM4EMEN1ALDH1A1HPGD | |
| SCHEMBL3579908 | 0.65 | PARP1 (0.61) | PARP1KDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL6804468 | 0.64 | PARP1 (0.40) | PARP1PRKD3ROCK1PRKD2DHODH | |
| SCHEMBL17048129 | 0.64 | KDM4E (0.56) | PARP1KDM4EALDH1A1HPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6696437-B1 | Heterocyclically substituted benzimidazoles, the production and application thereof | ABBOTT GMBH & CO. KG (DE) | 2004-02-24 | — | — | US | disclosed |