Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.39 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6805550 | 0.82 | SLC22A12 (0.43) | FFAR1 | |
| SCHEMBL6802634 | 0.80 | RAB9A (0.48) | RAB9AKMT2AFFAR1AKR1B1MEN1 | |
| SCHEMBL7247418 | 0.76 | KMT2A (0.43) | ADAM17KMT2ATSHRNPBWR1MEN1 | |
| SCHEMBL6806069 | 0.73 | ADAM17 (0.39) | RAB9AADAM17FFAR1PARP10NPC1 | |
| SCHEMBL3970211 | 0.72 | ADAM17 (0.57) | ADAM17 | |
| SCHEMBL6805048 | 0.72 | LMNA (0.58) | RAB9AFFAR1PARP10CYP1A2LMNA | |
| SCHEMBL6799652 | 0.70 | APP (0.58) | RAB9AKMT2AFFAR1MEN1CYP1A2 | |
| SCHEMBL6804822 | 0.70 | SMN1; SMN2 (0.54) | RAB9AKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL6809153 | 0.70 | ADAMTS4 (0.42) | RAB9AFFAR1PARP10NPC1MAPT | |
| SCHEMBL6803571 | 0.69 | RAB9A (0.40) | RAB9AKMT2AMEN1PARP10LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6770647-B2 | Bicyclic hydroxamates as inhibitors of matrix metalloproteinases and/or TNF-α converting enzyme (TACE) | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2004-08-03 | — | — | US | disclosed |
| WO-2003016248-A2 | BICYCLIC HYDROXAMATES AS INHIBITORS OF MATRIX METALLOPROTEINASES AND/OR TNF-$G(A) CONVERTING ENZYME (TACE) | BRISTOL-MYERS SQUIBB COMPANY PATENT DEPARTMENT (US) | 2003-02-27 | — | — | WO | disclosed |