Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | MAOB | P27338 | 6/20 | 0.37 |
| ▸ | MAOA | P21397 | 3/20 | 0.37 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.36 |
| ▸ | TEC | P42680 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | PDE2A | O00408 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6804907 | 0.90 | MAOB (0.41) | GRM5RAB9ANPC1ALDH1A1MAOB | |
| SCHEMBL6803571 | 0.90 | RAB9A (0.40) | RAB9APOLBMAOBMAOAPARP10 | |
| SCHEMBL6810689 | 0.84 | MAPT (0.39) | GRM5RAB9ANPC1ALDH1A1POLB | |
| SCHEMBL6804848 | 0.83 | PDE2A (0.42) | RAB9ANPC1ALDH1A1POLBMAOB | |
| SCHEMBL6804479 | 0.78 | MAOB (0.47) | MAOBMAOA | |
| SCHEMBL6804913 | 0.78 | PARP10 (0.56) | ALDH1A1MAOBMAOAPARP10MAPT | |
| SCHEMBL6804893 | 0.77 | SOD1 (0.42) | RAB9ANPC1ALDH1A1MAOBMAOA | |
| SCHEMBL6804575 | 0.77 | FFAR1 (0.42) | RAB9ANPC1ALDH1A1MAPTKDM4E | |
| SCHEMBL6803414 | 0.76 | RAB9A (0.43) | RAB9ANPC1POLBMAOBMEN1 | |
| SCHEMBL6802634 | 0.73 | RAB9A (0.48) | RAB9ANPC1MAOBMAOAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6770647-B2 | Bicyclic hydroxamates as inhibitors of matrix metalloproteinases and/or TNF-α converting enzyme (TACE) | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2004-08-03 | — | — | US | disclosed |
| WO-2003016248-A2 | BICYCLIC HYDROXAMATES AS INHIBITORS OF MATRIX METALLOPROTEINASES AND/OR TNF-$G(A) CONVERTING ENZYME (TACE) | BRISTOL-MYERS SQUIBB COMPANY PATENT DEPARTMENT (US) | 2003-02-27 | — | — | WO | disclosed |