Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 10/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | PDE2A | O00408 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6803571 | 0.82 | RAB9A (0.40) | PDE2ASMN1; SMN2RAB9A | |
| SCHEMBL6804638 | 0.77 | GRM5 (0.41) | MAPTKDM4EALDH1A1PDE2AHPGD | |
| SCHEMBL6804848 | 0.76 | PDE2A (0.42) | ALDH1A1PDE2ASMN1; SMN2NPC1RAB9A | |
| SCHEMBL6804893 | 0.75 | SOD1 (0.42) | MAPTALDH1A1HPGDSMN1; SMN2NPC1 | |
| SCHEMBL3970211 | 0.74 | ADAM17 (0.57) | — | |
| SCHEMBL6804913 | 0.73 | PARP10 (0.56) | FFAR1MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL6803414 | 0.71 | RAB9A (0.43) | FFAR1PDE2ASMN1; SMN2NPC1RAB9A | |
| SCHEMBL6804907 | 0.71 | MAOB (0.41) | ALDH1A1NPC1RAB9A | |
| SCHEMBL6800379 | 0.71 | ALDH1A1 (0.63) | MAPTKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL6806069 | 0.70 | ADAM17 (0.39) | FFAR1MAPTKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6770647-B2 | Bicyclic hydroxamates as inhibitors of matrix metalloproteinases and/or TNF-α converting enzyme (TACE) | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2004-08-03 | — | — | US | disclosed |
| WO-2003016248-A2 | BICYCLIC HYDROXAMATES AS INHIBITORS OF MATRIX METALLOPROTEINASES AND/OR TNF-$G(A) CONVERTING ENZYME (TACE) | BRISTOL-MYERS SQUIBB COMPANY PATENT DEPARTMENT (US) | 2003-02-27 | — | — | WO | disclosed |