Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 12/20 | 0.37 |
| ▸ | CHEK2 | O96017 | 5/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.35 |
| ▸ | KDR | P35968 | 2/20 | 0.35 |
| ▸ | PLK4 | O00444 | 2/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.33 |
| ▸ | PRKX | P51817 | 2/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.33 |
| ▸ | PKN1 | Q16512 | 2/20 | 0.33 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.33 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.33 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.33 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.33 |
| ▸ | PRKACA | P17612 | 1/20 | 0.33 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6804750 | 0.84 | PARP1 (0.57) | PARP1CHEK2AURKBPLK4MAP4K4 | |
| SCHEMBL6807111 | 0.82 | PARP1 (0.46) | PARP1CHEK2AURKBKDRPLK4 | |
| SCHEMBL6806385 | 0.80 | CHEK2 (0.40) | PARP1CHEK2 | |
| SCHEMBL6807301 | 0.79 | PARP1 (0.39) | PARP1CHEK2AURKBKDRPLK4 | |
| SCHEMBL6801835 | 0.78 | AURKB (0.44) | PARP1CHEK2AURKBKDRPLK4 | |
| SCHEMBL6804968 | 0.76 | PARP1 (0.49) | PARP1CHEK2AURKBKDR | |
| SCHEMBL6806674 | 0.74 | PARP1 (0.39) | PARP1CHEK2AURKBKDRPLK4 | |
| SCHEMBL6588648 | 0.73 | PARP1 (0.40) | PARP1CHEK2AURKBKDRPLK4 | |
| SCHEMBL3579908 | 0.72 | PARP1 (0.61) | PARP1CHEK2AURKBPLK4MAP4K4 | |
| SCHEMBL6804468 | 0.71 | PARP1 (0.40) | PARP1CHEK2AURKBPLK4MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6696437-B1 | Heterocyclically substituted benzimidazoles, the production and application thereof | ABBOTT GMBH & CO. KG (DE) | 2004-02-24 | — | — | US | disclosed |