Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | NPBWR1 | P48145 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 5/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | KCNMA1 | Q12791 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.33 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.33 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.33 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.33 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6806378 | 0.86 | PARP1 (0.57) | CHEK2PARP1 | |
| SCHEMBL6807111 | 0.81 | PARP1 (0.46) | CHEK2PARP1MEN1KMT2A | |
| SCHEMBL6804756 | 0.80 | PARP1 (0.37) | CHEK2PARP1 | |
| SCHEMBL6587178 | 0.77 | PARP1 (0.41) | CHEK2PARP1MAPTNPBWR1MEN1 | |
| SCHEMBL7480129 | 0.74 | MGAM (0.52) | PARP1MAPTPOLBHPGDNPBWR1 | |
| SCHEMBL6807301 | 0.74 | PARP1 (0.39) | CHEK2PARP1 | |
| SCHEMBL6801835 | 0.73 | AURKB (0.44) | CHEK2PARP1 | |
| SCHEMBL6804968 | 0.71 | PARP1 (0.49) | CHEK2PARP1ALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL6806674 | 0.69 | PARP1 (0.39) | CHEK2PARP1 | |
| SCHEMBL6810614 | 0.68 | MAP4K4 (0.52) | CHEK2PARP1MAPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6696437-B1 | Heterocyclically substituted benzimidazoles, the production and application thereof | ABBOTT GMBH & CO. KG (DE) | 2004-02-24 | — | — | US | disclosed |