Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 5/20 | 0.53 |
| ▸ | NOD2 | Q9HC29 | 5/20 | 0.53 |
| ▸ | NOD1 | Q9Y239 | 5/20 | 0.53 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | PKLR | P30613 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6814026 | 0.85 | NOD1 (0.41) | TNFNOD2NOD1LMNAMAPT | |
| SCHEMBL2209599 | 0.82 | LMNA (0.68) | TNFNOD2NOD1NOTUMLMNA | |
| SCHEMBL2205547 | 0.82 | LMNA (0.68) | TNFNOD2NOD1NOTUMLMNA | |
| SCHEMBL12428954 | 0.82 | LMNA (0.68) | TNFNOD2NOD1NOTUMLMNA | |
| SCHEMBL26079156 | 0.78 | NOTUM (0.64) | TNFNOD2NOD1NOTUMMAPT | |
| SCHEMBL7416927 | 0.76 | NOTUM (0.62) | TNFNOD2NOD1NOTUMLMNA | |
| SCHEMBL7169094 | 0.75 | TP53 (0.40) | TNFNOD2NOD1LMNAMAPT | |
| SCHEMBL6805438 | 0.74 | ALDH1A1 (0.53) | TNFNOD2NOD1NOTUMLMNA | |
| SCHEMBL8567503 | 0.74 | NOTUM (0.59) | TNFNOD2NOD1NOTUMMAPT | |
| SCHEMBL32673424 | 0.74 | NOTUM (0.62) | TNFNOD2NOD1NOTUMLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6825225-B2 | useful against a number of human and veterinary pathogens, including gram-positive aerobic bacteria such as multiply-resistant staphylococci and streptococci, anaerobic organisms such as bacteroides and clostridia species, and acid-fast organisms | PHARMACIA & UPJOHN COMPANY | 2004-11-30 | — | — | US | disclosed |
| US-20040116413-A1 | Novel bicyclic isoxazolinones as antibacterial agents | PHARMACIA & UPJOHN COMPANY | 2004-06-17 | — | — | US | disclosed |