Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | NOD1 | Q9Y239 | 3/20 | 0.38 |
| ▸ | TNF | P01375 | 2/20 | 0.38 |
| ▸ | NOD2 | Q9HC29 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6814026 | 0.80 | NOD1 (0.41) | TP53RAB9ANOD1TNFNOD2 | |
| SCHEMBL6813708 | 0.76 | ALDH1A1 (0.34) | TP53ALDH1A1RAB9ANPC1KMT2A | |
| SCHEMBL6805435 | 0.75 | TNF (0.53) | RAB9ANOD1TNFNOD2LMNA | |
| SCHEMBL6813709 | 0.68 | BCL9 (0.36) | ALDH1A1KMT2AGAAMEN1MAPT | |
| SCHEMBL2209599 | 0.65 | LMNA (0.68) | ALDH1A1RAB9ANOD1TNFNOD2 | |
| SCHEMBL2205547 | 0.65 | LMNA (0.68) | ALDH1A1RAB9ANOD1TNFNOD2 | |
| SCHEMBL12428954 | 0.65 | LMNA (0.68) | ALDH1A1RAB9ANOD1TNFNOD2 | |
| SCHEMBL28570413 | 0.65 | HIF1A (0.43) | ALDH1A1KMT2AGAAMAPT | |
| SCHEMBL11023644 | 0.64 | BCL9 (0.70) | ALDH1A1RAB9AKMT2ASMN1; SMN2LMNA | |
| SCHEMBL28518145 | 0.64 | KMT2A (0.49) | TP53ALDH1A1KMT2ASMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1334090-A1 | NOVEL BICYCLIC ISOXAZOLINONES AS ANTIBACTERIAL AGENTS | PHARMACIA & UPJOHN COMPANY (US) | 2003-08-13 | — | — | EP | disclosed |
| WO-2002102785-A1 | NOVEL BICYCLIC ISOXAZOLINONES AS ANTIBACTERIAL AGENTS | PHARMACIA & UPJOHN COMPANY (US) | 2002-12-27 | — | — | WO | disclosed |