Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.33 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.33 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 6/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 4/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | NEK2 | P51955 | 1/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6805973 | 0.92 | TDP1 (0.43) | TDP1KMT2APOLBMAPTALDH1A1 | |
| SCHEMBL6805979 | 0.89 | CNR1 (0.41) | TDP1CNR1CNR2KMT2AMAPT | |
| SCHEMBL6810273 | 0.87 | TDP1 (0.36) | TDP1CNR1CNR2KMT2APOLB | |
| SCHEMBL6806629 | 0.85 | TDP1 (0.35) | TDP1KMT2ASIRT2SIRT1SIRT3 | |
| SCHEMBL6801255 | 0.83 | TDP1 (0.40) | TDP1CNR1CNR2KMT2APOLB | |
| SCHEMBL4640097 | 0.82 | TDP1 (0.36) | TDP1CNR1CNR2KMT2APOLB | |
| SCHEMBL6810547 | 0.80 | ITGB3 (0.40) | TDP1CNR1CNR2 | |
| SCHEMBL6805959 | 0.79 | ITGB3 (0.40) | TDP1KMT2APOLBMAPTALDH1A1 | |
| SCHEMBL6805470 | 0.79 | TDP1 (0.36) | TDP1KMT2AMAPTMEN1RXFP1 | |
| SCHEMBL6811105 | 0.78 | CNR1 (0.44) | CNR1CNR2ALDH1A1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6723727-B1 | VITRONECTIN RECEPTOR ANTAGONISTS; INHIBITORS OF BONE RESORPTION; OSTEOPOROSIS | HOECHST AKTIENGESELLSCHAFT (DE) | 2004-04-20 | — | — | US | disclosed |