SCHEMBL6807930

SCHEMBL6807930

CC(=O)Nc1cccc(OC(C(=O)Nc2cccc(C(=N)N)c2)c2ccccc2)c1

nearest known ligand 0.60

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
F10 P00742 13/20 0.60
PRSS1 P07477 8/20 0.60
PLAU P00749 7/20 0.55
F9 P00740 3/20 0.55
F2 P00734 3/20 0.53
PLG P00747 1/20 0.52
PLAT P00750 1/20 0.52
KLKB1 P03952 1/20 0.52
POLB P06746 1/20 0.52
SMN1; SMN2 Q16637 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6806834 0.91 POLB (0.54) F10PRSS1PLAUF9POLB
SCHEMBL6807765 0.91 F10 (0.62) F10PRSS1PLAUF9F2
SCHEMBL6808022 0.81 LMNA (0.49) SMN1; SMN2
SCHEMBL5166349 0.81 F10 (0.66) F10PRSS1PLAUF9F2
SCHEMBL1436168 0.80 ALDH1A1 (0.59) F10POLBSMN1; SMN2
SCHEMBL7114682 0.79 F10 (0.68) F10PRSS1PLAUF9F2
SCHEMBL7120375 0.79 F10 (0.57) F10PRSS1F2PLG
SCHEMBL6807833 0.79 F10 (0.73) F10PRSS1F2PLG
Hydrochloric Acid SCHEMBL3576551 0.79 ALDH1A1 (0.57) F10PLAUPOLBSMN1; SMN2
SCHEMBL6802380 0.79 HTT (0.47) F10PLAUF9POLBSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20040092517-A1 Phenyl derivatives and their use in the treatment of thromboembolic disorders or tumours MERCK PATENT GMBH (DE) 2004-05-13 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040092517-A1 Phenyl derivatives and their use in the treatment of thromboembolic disorders or tumours RCOR3, F2, NCOR2 F10 64/4885PRSS1 1089/4885PLAU 1851/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.