SCHEMBL6808384

SCHEMBL6808384

CCC(=O)Oc1ccc(C(=O)CC)cc1C

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 6/20 0.49
GAA P10253 3/20 0.49
ACHE P22303 1/20 0.49
MEN1 O00255 1/20 0.47
ALOX15 P16050 1/20 0.46
THRA P10827 1/20 0.46
THRB P10828 1/20 0.46
KDM4E B2RXH2 3/20 0.46
HPGD P15428 3/20 0.46
GLA P06280 2/20 0.46
HSD17B10 Q99714 2/20 0.46
LMNA P02545 1/20 0.46
MAPK1 P28482 1/20 0.46
SMN1; SMN2 Q16637 2/20 0.45
ESR1 P03372 2/20 0.45
HIF1A Q16665 2/20 0.45
RECQL P46063 1/20 0.45
TAS1R3 Q7RTX0 3/20 0.44
TAS1R1 Q7RTX1 3/20 0.44
PPARA Q07869 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3948073 0.83 MEN1 (0.60) KMT2AMEN1ALOX15KDM4EHPGD
SCHEMBL28162947 0.82 PDE4B (0.47) KMT2AMEN1THRATHRBKDM4E
SCHEMBL6816782 0.82 MAPT (0.49) KMT2AGAAMEN1ALOX15THRA
SCHEMBL7537504 0.81 L3MBTL1 (0.59) KMT2AGAAACHEMEN1ALOX15
SCHEMBL19774166 0.79 ACHE (0.51) KMT2AGAAACHEMEN1ALOX15
SCHEMBL11332752 0.79 ACHE (0.59) KMT2AGAAACHEALOX15KDM4E
SCHEMBL11073030 0.79 MEN1 (0.49) KMT2AMEN1THRATHRBKDM4E
SCHEMBL6812398 0.78 MEN1 (0.43) KMT2AMEN1THRATHRBKDM4E
SCHEMBL20593459 0.78 ALOX15 (0.55) KMT2AGAAACHEALOX15KDM4E
SCHEMBL6962227 0.78 ACHE (0.50) KMT2AGAAACHEALOX15KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0828513-B1 COMBINATIONS FOR THE TREATMENT OF PARKINSONISM CONTAINING SELECTIVE NMDA ANTAGONISTS PFIZER (US) 2004-01-21 EP disclosed
EP-0777652-B1 NEUROPROTECTIVE 3-(PIPERIDINYL-1)-CHROMAN-4,7-DIOL AND 1-(4-HYDROPHENYL)-2-(PIPERIDINYL-1)-ALKANOL DERIVATIVES PFIZER (US) 2003-06-25 EP disclosed
US-6258827-B1 HYDROXYAROMATIC HETEROCYCLIC ALKANOLS AND LEVODOPA PFIZER INC. 2001-07-10 US disclosed
US-6046213-A Neuroprotective 3-(piperidinyl-1)-chroman-4,7-diol and 1-(4-hydroxyphenyl)-2-(piperidinyl-1)-alkanol derivatives PFIZER INC. (US) 2000-04-04 US disclosed
EP-0828513-A2 COMBINATIONS FOR THE TREATMENT OF PARKINSONISM CONTAINING SELECTIVE NMDA ANTAGONISTS PFIZER INC. (US) 1998-03-18 EP disclosed
EP-0777652-A1 NEUROPROTECTIVE 3-(PIPERIDINYL-1)-CHROMAN-4,7-DIOL AND 1-(4-HYDROPHENYL)-2-(PIPERIDINYL-1)-ALKANOL DERIVATIVES PFIZER INC. (US) 1997-06-11 EP disclosed
WO-1996037226-A2 COMBINATIONS FOR THE TREATMENT OF PARKINSONISM CONTAINING SELECTIVE NMDA ANTAGONISTS PFIZER INC. (US) 1996-11-28 WO disclosed
WO-1996006081-A1 NEUROPROTECTIVE 3-(PIPERIDINYL-1)-CHROMAN-4,7-DIOL AND 1-(4-HYDROPHENYL)-2-(PIPERIDINYL-1)-ALKANOL DERIVATIVES PFIZER INC. (US) 1996-02-29 WO disclosed