Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | HMGCR | P04035 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | ESR1 | P03372 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9720571 | 0.82 | HMGCR (0.56) | KMT2AHMGCRKDM4EHPGDALDH1A1 | |
| SCHEMBL6808384 | 0.78 | KMT2A (0.49) | ACHEKMT2AGAALMNAHTT | |
| SCHEMBL7953584 | 0.77 | HSP90AB1 (0.45) | KMT2AGAALMNAHTTHMGCR | |
| SCHEMBL29072064 | 0.77 | ACHE (0.54) | ACHEKMT2AGAALMNAHTT | |
| SCHEMBL13284211 | 0.77 | HMGCR (0.68) | KMT2AHTTHMGCRKDM4EHPGD | |
| SCHEMBL9720676 | 0.73 | HMGCR (0.58) | KMT2AHTTHMGCRKDM4EHSP90AB1 | |
| SCHEMBL8057944 | 0.72 | PPARA (0.45) | GAALMNAHTTALOX15HSD17B10 | |
| SCHEMBL28048673 | 0.72 | HSP90AB1 (0.50) | KMT2AHTTHMGCRALOX15HSD17B10 | |
| SCHEMBL7537504 | 0.71 | L3MBTL1 (0.59) | ACHEKMT2AGAALMNAHTT | |
| SCHEMBL11342543 | 0.71 | HMGCR (0.61) | KMT2AGAAHTTHMGCRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0777652-B1 | NEUROPROTECTIVE 3-(PIPERIDINYL-1)-CHROMAN-4,7-DIOL AND 1-(4-HYDROPHENYL)-2-(PIPERIDINYL-1)-ALKANOL DERIVATIVES | PFIZER (US) | 2003-06-25 | — | — | EP | disclosed |