Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 3/20 | 0.47 |
| ▸ | DRD3 | P35462 | 3/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.46 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.41 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.41 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.41 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.41 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | TDO2 | P48775 | 3/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | SCD | O00767 | 1/20 | 0.38 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.38 |
| ▸ | ME2 | P23368 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL941026 | 0.92 | DRD4 (0.53) | DRD4DRD3HTR1AHTR2ASLC6A4 | |
| SCHEMBL941651 | 0.87 | AKR1C3 (0.57) | AKR1C3GRIN2DGRIN3BGRIN1GRIN2A | |
| Hydrochloric Acid SCHEMBL6812180 | 0.84 | GPR119 (0.50) | DRD4DRD3HTR1AHTR2ASLC6A4 | |
| SCHEMBL17863633 | 0.83 | AKR1C3 (0.53) | AKR1C3GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL5238753 | 0.76 | DRD4 (0.55) | DRD4DRD3HTR1AHTR2ASLC6A4 | |
| SCHEMBL5236585 | 0.74 | AKR1C3 (0.61) | AKR1C3GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL31589397 | 0.72 | HTR1A (0.52) | DRD4DRD3HTR1AHTR2ASLC6A4 | |
| SCHEMBL12911528 | 0.71 | GPR119 (0.58) | DRD4DRD3HTR1AHTR2ASLC6A4 | |
| SCHEMBL1742814 | 0.70 | HRH3 (0.52) | DRD4DRD3HTR1AHTR2ASLC6A4 | |
| Hydrochloric Acid SCHEMBL942193 | 0.70 | GPR119 (0.56) | DRD4DRD3HTR1AHTR2ASLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040127528-A1 | Metalloproteinase inhibitors | ASTRAZENECA AB (SE) | 2004-07-01 | — | — | US | disclosed |
| EP-1370556-A1 | METALLOPROTEINASE INHIBITORS | AstraZeneca AB (SE) | 2003-12-17 | — | — | EP | disclosed |
| WO-2002074767-A1 | METALLOPROTEINASE INHIBITORS | ASTRAZENECA AB (SE) | 2002-09-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040127528-A1 | Metalloproteinase inhibitors | MMP9, MMP10, MMP3 | DRD4 4845/4885DRD3 4849/4885HTR1A 4269/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.